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AboutAboutMOA & IndicationsWhy Eliquis®?Dosage & SwitchDosage & SwitchSPAF DosingVTE DosingEfficacy & SafetyEfficacy & SafetyRCT Data: Efficacy and Safety in SPAFRCT Data: Efficacy and Safety in VTERCT Data: Efficacy and Safety in SPAFEliquis® in a Broad Range of Patients With NVAFApixaban & Other NOACsApixaban & Other NOACsApixaban & Other NOACsSupport & ServicesSupport & ServicesSummary of Prescribing InformationExpert Webinars

Eliquis® in a Broad Range of Patients With NVAF

Apixaban can benefit a broad range of patients with NVAF1,5-10,*

  

Patients with NVAF treated with apixaban had consistently fewer strokes and bleeds across a broad range of subgroup populations and risk profiles versus warfarin.1,5-10

  

  

 
*Patients with severe renal insufficiency (CrCl <25 mL/min) were excluded from ARISTOTLE.1
 

Recommended dose of apixaban for SPAF as per the Eliquis® India LPDELI052021 is 5 mg BID and 2.5 mg BID in patients with 2 or more of the following criteria: Serum creatinine ≥1.5 mg/dL, age ≥80 years and body weight ≤60 kg.

   

ARISTOTLE, Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation; BID, twice daily; CrCl, creatinine clearance; NVAF, non-valvular atrial fibrillation; SPAF, Stroke Prevention in Atrial Fibrillation; TIA, transient ischaemic attack.

   

References:

Granger CB, Alexander JH, McMurray JJ, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365(11):981-992.Ruff CT, Giugliano RP, Braunwald E, et al. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet. 2014;383(9921):955-962.Hur M, Park SK, Koo CH, et al. Comparative efficacy and safety of anticoagulants for prevention of venous thromboembolism after hip and knee arthroplasty. Acta Orthop. 2017;88(6):634-641.Cohen AT, Imfeld S, Rider T. Phase III trials of new oral anticoagulants in the acute treatment and secondary prevention of VTE: comparison and critique of study methodology and results. Adv Ther. 2014;31(5):473-493.Garcia DA, Wallentin L, Lopes RD, et al. Apixaban versus warfarin in patients with atrial fibrillation according to prior warfarin use: results from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial. Am Heart J. 2013;166(3):549-558.Eliquis. Local product document. Pfizer; 2022. LPDELI062022. Version 16.Hohnloser SH, Hijazi Z, Thomas L, et al. Efficacy of apixaban when compared with warfarin in relation to renal function in patients with atrial fibrillation: insights from the ARISTOTLE trial. Eur Heart J. 2012;33(22):2821-2830.Halvorsen S, Atar D, Yang H, et al. Efficacy and safety of apixaban compared with warfarin according to age for stroke prevention in atrial fibrillation: observations from the ARISTOTLE trial. Eur Heart J. 2014;35(28):1864-1872.Lopes RD, Al-Khatib SM, Wallentin L, et al. Efficacy and safety of apixaban compared with warfarin according to patient risk of stroke and of bleeding in atrial fibrillation: a secondary analysis of a randomized controlled trial. Lancet. 2012;380(9855):1749-1758.Easton JD, Lopes RD, Bahit MC, et al. Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of the ARISTOTLE trial. Lancet Neurol. 2012;11(6):503-511.

   

Disclaimer: The products discussed herein may have different product labelling in different countries. The product information provided in this site is intended only for the residents of India.

   

Please click the Prescribing Information link to view the safety and adverse events information of Eliquis®.
For the use only of Registered Medical Practitioners, or a hospital or a laboratory.

  

PP-ELI-IND-1567 25 July 2022

  

RCT Data: Efficacy and Safety in SPAFSPAF Dosing
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