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AboutAboutMOA & IndicationsWhy Eliquis®?Dosage & SwitchDosage & SwitchSPAF DosingVTE DosingEfficacy & SafetyEfficacy & SafetyRCT Data: Efficacy and Safety in SPAFRCT Data: Efficacy and Safety in VTERCT Data: Efficacy and Safety in SPAFEliquis® in a Broad Range of Patients With NVAFApixaban & Other NOACsApixaban & Other NOACsApixaban & Other NOACsSupport & ServicesSupport & ServicesSummary of Prescribing InformationExpert Webinars

SPAF Dosing

Choosing the right dose for your non-valvular AF patients at risk of stroke5

  

Initiating Apixaban 5 mg BID in patients with NVAF5
 


The ABC dose adjustment criteria

  • All patients with NVAF at the risk of stroke
     
  • In patients with at least 2 of the following characteristics, the dose reduction should be considered
     

   

Switching to Eliquis®

   

Switching to Apixaban5-7

   

   


ABC, age, body weight, creatinine; ASA, acetyl salicylic acid; BID, twice daily; INR, International Normalized Ratio; NOAC, non-vitamin K antagonist oral anticoagulant; NVAF, nonvalvular atrial fibrillation; VKA, vitamin K antagonist.

Reference:

Granger CB, Alexander JH, McMurray JJ, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365(11):981-992.Ruff CT, Giugliano RP, Braunwald E, et al. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet. 2014;383(9921):955-962.Hur M, Park SK, Koo CH, et al. Comparative efficacy and safety of anticoagulants for prevention of venous thromboembolism after hip and knee arthroplasty. Acta Orthop. 2017;88(6):634-641.Cohen AT, Imfeld S, Rider T. Phase III trials of new oral anticoagulants in the acute treatment and secondary prevention of VTE: comparison and critique of study methodology and results. Adv Ther. 2014;31(5):473-493.Eliquis. Local product document. Pfizer; 2022. LPDELI062022. Version 16.Steffel J, Collins R, Antz M, et al. 2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation. Europace. 2021.23;1612–1676.Steffel J, Collins R, Antz M, et al. External reviewers, 2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation. EHRA 2021 Supplementary data. EP Europace, 2021;23(10):1612–1676. Accessed July 19, 2022. Available at https://academic-oup-com.eres.qnl.qa/europace/article/23/10/1612/6247378#supplementary-data

  

Disclaimer: The products discussed herein may have different product labelling in different countries. The product information provided in this site is intended only for the residents of India.

   

Please click the Prescribing Information link to view the safety and adverse events information of Eliquis®.
For the use only of Registered Medical Practitioners, or a hospital or a laboratory.

  

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