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About CRESEMBA®About CRESEMBA®Meet CRESEMBA®CRESEMBA® in the ICUCRESEMBA® in ActionEfficacy EfficacyInvasive AspergillosisEfficacyGuidelines MucormycosisEfficacyGuidelinesSafetySafetyTolerabilityInvasive AspergillosisMucormycosis Safety ProfileSafety ProfileDosingDosingSimple DosingLinear PKs, Low Variability and TDMPractical ConsiderationsReal-world DataReal-world DataReal-world EffectivenessReal-world SafetyResourcesResourcesSummary of Prescribing InformationEventsMaterialsVideos

The latest second-generation azole1–3 designed to help your patients see through the storm

A treatment of choice for a growing number of patients4,5

  

Since launching in 2015, CRESEMBA® has helped more than 90,000 patients worldwide:4,5 

>91,000 patients treated4 Marketing authorisation in 46 countries5 >2.5 million patient days5 KickerComing Soon...The latest second-generation azole1–3

CRESEMBA®: specifically designed to facilitate IV administration, reducing the risk of renal toxicity associated with other azoles1,2,6,7

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The latest second-generation azole1–3

CRESEMBA®: specifically designed to facilitate IV administration, reducing the risk of renal toxicity associated with other azoles1,2,6,7

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The only azole approved for both invasive aspergillosis and mucormycosis1,2,6,8

CRESEMBA® offers an extended antimould spectrum across Aspergillus and Mucorales1,3,9–12

CRESEMBA® provides efficacy you can rely on even before a definitive diagnosis13,14

View Data
Suitable for the needs of your patients2,6,8,14 Compared with other azoles, CRESEMBA® has fewer drug–drug interactions, more predictable PKs, and better renal and hepatic tolerability, allowing it to be used in a variety of patients1,13–16

The flexibility of CRESEMBA® could help you manage your patient’s invasive fungal infection while keeping focus on their underlying condition1,14,15,17

 

View Flexibility

Example

Designed to overcome key azole limitations1,2,6–8 CRESEMBA® brings you IV and oral formulations that overcome important azole limitations7

The oral formulation has high bioavailability (98%), allowing for interchangeable IV and oral dosing1

Unlike other IV azoles, CRESEMBA® does not require potentially nephrotoxic excipients such as cyclodextrin and betadex sulfobutyl ether sodium (SBECD)1,2,6,7

 

View Dosing 

Further resources

 

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CRESEMBA® IV reconstitution, dilution and administration Watch Video
IV administration leaflet​​​​​​​ View Leaflet Patient booklet​​​​​​​ View Booklet

ICU, intensive care unit; IV, intravenous; PK, pharmacokinetic.


Prescribing Information:
CRESEMBA® (isavuconazole)

References:

Adapted from Local Product Document of CRESEMBA® (Isavuconazole) version LPDCRE052021.Adapted from Local Product Document of VFEND® (Voriconazole) version LPDVRC022022.Miceli MH and Kauffman CA. Clin Infect Dis 2015;61(10):1558–1565.Basilea. CRESEMBA® Periodic Safety Update Report 9. September 2020. DOF.Basilea. CRESEMBA® Global Core Dossier. 2020. DOF.Posaconazole Summary of Product Characteristics.Donnelley MA et al. Infect Drug Resist 2016;9:79–86.Itraconazole Summary of Product Characteristics.Arendrup MC et al. Antimicrob Agents Chemother 2015;59(12):7735–7742.Guinea J et al. PLoS One 2017;12(6):e0179136.Sabatelli F et al. Antimicrob Agents Chemother 2006;50(6):2009–2015.Amphotericin B liposomal Summary of Product Characteristics.Maertens JA et al. Lancet 2016;387(10020):760–769.Marty FM et al. Lancet Infect Dis 2016;16(7):828–837.Natesan SK and Chandrasekar PH. Infect Drug Resist 2016;9:291–300.Kaindl T et al. J Antimicrob Chemother 2019;74:761–767.Perfect JR. Nat Rev Drug Discov 2017;16(9):603–616.

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