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​​​​​​​Downloadable ResourcesAboutAboutMechanism of ActionGuidelinesClinical Efficacy  Clinical Efficacy ARCHER 1050: Study DesignEfficacy (PFS) in the ITT PopulationEfficacy (PFS) in the Asian PopulationEfficacy (ORR and DoR)Efficacy (mOS)

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Start With Proven First-line Efficacy1-3
 

Dacomitinib is a kinase inhibitor indicated for the first-line treatment of patients with metastatic NSCLC with EGFR exon 19 deletion or exon 21 L858R substitution mutations.3

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Videos

  • Dacomitinib-unbranded video
     
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  • Dacomitinib MOA animation

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Mechanism of Action

DACOPLICE® is a second-generation EGFR TKI

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Dosing & Therapy Management

Start with proven first-line efficacy​​​​​​​​​​​​​​​​​​​​​​​​​​​​​

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Clinical Efficacy

First-line use of DACOPLICE® was studied in a Phase III, head-to-head trial with gefitinib

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Safety Profile

ARCHER 1050 study reported the most common adverse events in patients

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Guidelines

DACOPLICE® is recommended by clinical practice guidelines

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Pfizer Limited

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To view the summary of prescribing information for DACOPLICE®, please click here.

For the use only of Registered Medical Practitioners or a Hospital or a Laboratory. Full prescribing information available on request.


ARCHER, Adolescent Rural Cohort on Hormones, Education, Environment, Health and Relationships; EGFR, epidermal growth factor receptor; MoA, mechanism of action; NSCLC, non-small cell lung cancer; TKI, tyrosine kinase inhibitor.

References:

Wu YL, Cheng Y, Zhou X, et al. Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer (ARCHER 1050): a randomised, open-label, phase 3 trial. Lancet Oncol. 2017;18(11):1454-1466.Mok TS, Cheng Y, Zhou X, et al. Improvement in overall survival in a randomized study that compared dacomitinib with gefitinib in patients with advanced non-small-cell lung cancer and EGFR-activating mutations. J Clin Oncol. 2018;36(22):2244-2250.Dacoplice. Local product document. Pfizer; 2021. Version LPDDAC042021.

     

Please click the Prescribing Information link to view the safety and adverse events information of DACOPLICE®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

     

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These pages are not intended for patients or for members of the general public. The web pages contain promotional content. For the use only of Registered Medical Practitioners or a Hospital or a Laboratory. Full prescribing information available on request. For more details on, Who is a Registered Medical Practitioner, please visit "https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf", Page No. 39, Rule 2 part (ee), last accessed on 26th April2021.
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