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​​​​​​​Downloadable ResourcesAboutAboutMechanism of ActionGuidelinesClinical Efficacy  Clinical Efficacy ARCHER 1050: Study DesignEfficacy (PFS) in the ITT PopulationEfficacy (PFS) in the Asian PopulationEfficacy (ORR and DoR)Efficacy (mOS)

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Start With Proven First-line Efficacy1-3
 

Dacomitinib is a kinase inhibitor indicated for the first-line treatment of patients with metastatic NSCLC with EGFR exon 19 deletion or exon 21 L858R substitution mutations.3

H3 (Mobile)

Latest Articles

A RWS of dacomitinib in advanced NSCLC patients harbouring EGFR mutations in later-line settings
 

This real-world study has shown that dacomitinib is active and well-tolerated in patients with NSCLC harbouring different EGFR mutations in later-line settings, even for those with brain metastases.

       
     
Click to view

Efficacy of dacomitinib in patients with EGFR-mutated NSCLC and brain metastases
 

Dacomitinib demonstrated CNS efficacy in patients with EGFR TKI-naïve EGFR-mutated NSCLC in the real-world setting.

       
     
Click to view

A review on progression of EGFR inhibitors as an efficient approach in cancer targeted therapy
 

In this review, highlighted the importance of targeting EGFR signaling pathway in cancer therapy and related epigenetic mutations and reviewed the recent advances on the discovery and development of different EGFR inhibitors and the use of various therapeutic strategies such as multi-targeting agents and combination therapies.

       
     
Click to view

   

CNS, central nervous system; EGFR, epidermal growth factor receptor; NSCLC, non-small cell lung cancer; TKI,
tyrosine kinase inhibitor.

References:

Wu YL, Cheng Y, Zhou X, et al. Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer (ARCHER 1050): a randomised, open-label, phase 3 trial. Lancet Oncol. 2017;18(11):1454-1466.Mok TS, Cheng Y, Zhou X, et al. Improvement in overall survival in a randomized study that compared dacomitinib with gefitinib in patients with advanced non-small-cell lung cancer and EGFR-activating mutations. J Clin Oncol. 2018;36(22):2244-2250.Dacoplice. Local product document. Pfizer; 2021. Version LPDDAC042021.

    

Please click the Prescribing Information link to view the safety and adverse events information of DACOPLICE®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

     

PP-DAC-IND-0147 June 2022

    

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Mechanism of Action

DACOPLICE® is a second-generation EGFR TKI​​​​

Learn more


Dosing & Therapy Management

Start with proven first-line efficacy

Learn more


Clinical Efficacy

First-line use of DACOPLICE® was studied in a Phase III, head-to-head trial with gefitinib

Review efficacy profile


Safety Profile

ARCHER 1050 study reported the most common adverse events in patients

Review safety profile

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