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AboutAboutExtended CoveragePK and PD ProfileGood Safety ProfileGuidelines and RecommendationsDosingRecommended DosageAdultsSpecial PopulationEfficacyIntra-abdominal InfectionRisk factorClinical efficacyUrinary Tract InfectionRisk factorClinical efficacyRespiratory Tract InfectionResistance rateImpactClinical efficacyFebrile NeutropeniaRisk factorTreatmentClinical efficacySafetyClinical & Scientific DataSupport & ResourcesSupport & ResourcesClinical UpdatesPrescribing InformationVideosWebinarsExplore Materials

Indication: Monotherapy – Sulbactam/Cefoperazone is indicated for the treatment of the following infections when caused by susceptible organisms: Respiratory tract infections, urinary tract infections (upper and lower), intra-abdominal infections, septicaemia, meningitis, skin and soft tissue infections, bone and joint infections, endometritis and other infections in the genital tract. MAGNEX® FORTE is indicated for a specific subset of patients (patients with immunocompromised febrile neutropenic cancer, patients who have undergone a bone marrow transplant).1

Extended Coverage

Cefoperazone/Sulbactam: Extended coverage with β-lactamase inhibition

 

Example


Adapted from Lai CC, et al. 2018.
​​​​​​​

The synergistic in vitro antibacterial activity of the cefoperazone + sulbactam combination results in lower MICs compared with cefoperazone alone for a wide range of pathogens.
Cefoperazone/Sulbactam enhances cefoperazone activity against most MDROs excluding carbapenem-resistant P. aeruginosa, and the activity is greatest at a ratio of 1:2, followed by ratios of 1:1 and 2:1.2



ESBL, extended-spectrum β-lactamase; MDRO, multidrug-resistant organism; MIC, minimum inhibitory concentration.


References:

Magnex. Local product document. Pfizer; 2020. Version LPDMGX042020.​​​​​​​
Lai CC, Chen CC, Lu YC, Lin TP, Chuang YC, Tang HJ. Appropriate composites of cefoperazone/sulbactam against multidrug-resistant organisms. Infect Drug Resist. 2018;11:1441-1445.


Please click the Prescribing Information link to view the safety and adverse events information of MAGNEX®.

For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.


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Please see full Prescribing Information for PRODUCT, including BOXED WARNING.


Dosing

Recommended dosage in adult ​​​​​​and special population​​​​​​​

Learn more


Efficacy

Cefoperazone/Sulbactam is recommended as an effective and well-tolerated antibiotic

Review efficacy profile


Safety

Explore the safety profile of cefoperazone/sulbactam​​​​​​​

Review safety profile


Clinical & Scientific Data

Cefoperazone/Sulbactam is more efficient in the treatment ​​​​​​​of infection​​​​​​​

Learn more




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These pages are not intended for patients or for members of the general public. The web pages contain promotional content. For the use only of Registered Medical Practitioners or a Hospital or a Laboratory. Full prescribing information available on request. For more details on, Who is a Registered Medical Practitioner, please visit "https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf", Page No. 39, Rule 2 part (ee), last accessed on 26th April2021.
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For more details on, Who is a Registered medical practitioner*, please visit https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf , Page No. 39, Rule 2 part (ee), last accessed on 26th April 2021.
Address: The Capital, A Wing, 1802, 18th Floor, Plot No. C-70, 'G' Block, Bandra Kurla Complex, Bandra East, Mumbai - 400051.


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