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AboutAboutExtended CoveragePK and PD ProfileGood Safety ProfileGuidelines and RecommendationsDosingRecommended DosageAdultsSpecial PopulationEfficacyIntra-abdominal InfectionRisk factorClinical efficacyUrinary Tract InfectionRisk factorClinical efficacyRespiratory Tract InfectionResistance rateImpactClinical efficacyFebrile NeutropeniaRisk factorTreatmentClinical efficacySafetyClinical & Scientific DataSupport & ResourcesSupport & ResourcesClinical UpdatesPrescribing InformationVideosWebinarsExplore Materials

Indication: Monotherapy – Sulbactam/Cefoperazone is indicated for the treatment of the following infections when caused by susceptible organisms: Respiratory tract infections, urinary tract infections (upper and lower), intra-abdominal infections, septicaemia, meningitis, skin and soft tissue infections, bone and joint infections, endometritis and other infections in the genital tract. MAGNEX® FORTE is indicated for a specific subset of patients (patients with immunocompromised febrile neutropenic cancer, patients who have undergone a bone marrow transplant).1

Guidelines & Recommendations

The ICMR guidelines on the management of IAI with cefoperazone/sulbactam2

  • First-choice antibiotic for CA-IAI of mild-to-moderate severity2

  • Cefoperazone/Sulbactam 3 g IV 12 hourly for the treatment of IAI, specifically for biliary tract infections2

Cefoperazone/Sulbactam is effective in3



Adapted from Mazuski JE, et al. 2017.

One of the ICMR-recommended antibiotics for the treatment of UTI2

The ICMR recommends cefoperazone/sulbactam 3 g IV 12 hourly for the treatment of:



Adapted from ICMR. 2019; Bharara T, et al. 2018.

The SIS guidelines on the management of IAI: Selection of empiric antimicrobial therapy for adult patients with CA-IAI3


Adapted from Mazuski JE, et al. 2017.



CA-IAI, community-acquired intra-abdominal infection; ESBL, extended-spectrum β-lactamase; IAI, intra-abdominal infection; ICMR, Indian Council of Medical Research; IV, intravenous; SIS, Surgical Infection Society; UTI, urinary tract infection.
​​​​​​​​​​​​​​

References:

Magnex. Local product document. Pfizer; 2020. Version LPDMGX042020.

​​​​​​​​​​​​​​ICMR. Treatment Guidelines for Antimicrobial Use in Common Syndromes. 2nd ed. ICMR; 2019:1-206.

Mazuski JE, Tessier JM, May AK, et al. The Surgical Infection Society revised guidelines on the management of intra-abdominal infection. Surg Infect (Larchmt). 2017;18(1):1-76.

Bharara T, Sharma A, Gur R, Duggal SD, Jena PP, Kumar A. Comparative analysis of extended-spectrum beta-lactamases producing uropathogens in outpatient and inpatient departments. Int J Health Allied Sci. 2018;7(1):45-50.


Please click the Prescribing Information link to view the safety and adverse events information of MAGNEX®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.


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About


Dosing

Recommended dosage in adult ​​​​​​and special population​​​​​​​

Learn more


Efficacy

Cefoperazone/Sulbactam is recommended as an effective and well-tolerated antibiotic

Review efficacy profile


Safety

Explore the safety profile of cefoperazone/sulbactam​​​​​​​

Review safety profile


Clinical & Scientific Data

Cefoperazone/Sulbactam is more efficient in the treatment ​​​​​​​of infection​​​​​​​

Learn more
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These pages are not intended for patients or for members of the general public. The web pages contain promotional content. For the use only of Registered Medical Practitioners or a Hospital or a Laboratory. Full prescribing information available on request. For more details on, Who is a Registered Medical Practitioner, please visit "https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf", Page No. 39, Rule 2 part (ee), last accessed on 26th April2021.
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