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Indication: Monotherapy – Sulbactam/Cefoperazone is indicated for the treatment of the following infections when caused by susceptible organisms: Respiratory tract infections, urinary tract infections (upper and lower), intra-abdominal infections, septicaemia, meningitis, skin and soft tissue infections, bone and joint infections, endometritis and other infections in the genital tract. MAGNEX® FORTE is indicated for a specific subset of patients (patients with immunocompromised febrile neutropenic cancer, patients who have undergone a bone marrow transplant).1

Clinical Efficacy & Tolerability

Antimicrobial activity of cefoperazone/sulbactam

  

Cefoperazone/Sulbactam shows antimicrobial activity against ESBL-producing E. coli and K. pneumoniae organisms1

  

Cefoperazone/Sulbactam in patients with VAP due to CRAB strains

  

Adjunctive therapy with CEP-SUL+ had lower mortality rates and resource utilisation compared with CEP-SUL- in patients with VAP due to CRAB strains3

  • Thirty-day and in-hospital mortality rates for CEP-SUL+ were significantly lower than CEP-SUL with values of 35%, 39% and 61%, 68%, for CEP-SUL+ and CEP-SUL, respectively3
     
  • The survival rate for CEP-SUL+ was significantly higher compared with CEP-SUL (P<0.001)3
     
  • The number of hospital days, ventilator days since diagnosis of VAP and hospital costs were lower for CEP-SUL+3 

  

Adapted from Kanchanasuwan S, et al. 2021.

  

BL/BLIs in infections with ESBL-producing strains

  • In children with high risk of ESBL-producing UTI pathogens or in children with severe sepsis/septic shock, empiric therapy should be initiated with BL/BLI combinations (piperacillin-tazobactam/cefoperazone-sulbactam) or carbapenems4
     
  • In a study which constituted 75.7% of patients with ESBL-producing microbes, the strains were sensitive carbapenems, piperacillin-tazobactam and cefoperazone-sulbactam. The organisms had a 3% resistance to imipenem and 41%, 29.5% and 30.3% resistance to amikacin, piperacillin-tazobactam and cefoperazone-sulbactam, respectively5
The SENTRY Antimicrobial Surveillance Programme dataThe SENTRY antimicrobial surveillance programme data: Cefoperazone/Sulbactam was among the most active compounds against gram-negative organisms from Europe, APAC and Latin.6

Cefoperazone/Sulbactam continues to demonstrate good in vitro activity against Enterobacterales and P. aeruginosa isolates from the APAC region.6
  • In all, 82% to 94.4% of Enterobacterales were susceptible to cefoperazone/sulbactam at ≤16 mg/L6
     
  • In all, 59.5% to 84.6% of P. aeruginosa were susceptible to cefoperazone/sulbactam at ≤16 mg/L6

Adapted from Sader HS, et al. 2020.

Adapted from Sader HS, et al. 2020.

*In patients using cefoperazone/sulbactam with or without combination with antimicrobial drugs, n=60. Combinations used were cefoperazone/sulbactam combined with minocycline, levofloxacin and meropenem.

AE, adverse event; APAC, Asia-Pacific; BL, beta-lactam; BLI, beta-lactamase inhibitor; CDAD, Clostridium difficile-associated diarrhoea; CEP-SUL−, patients who did not receive cefoperazone/sulbactam; CEP-SUL+, patients who received cefoperazone/sulbactam; CI, confidence interval; CRAB, carbapenem-resistant Acinetobacter baumannii; E-EU, Eastern Europe and Mediterranean; ESBL, extended-spectrum beta-lactamase; HAP, hospital-acquired pneumonia; LATAM, Latin America; RCT, randomised controlled trial; RR, risk ratio; VAP, ventilator-associated pneumonia; UTI, urinary tract infection; W-EU, Western Europe.

References:

Gupta D, Agarwal R, Aggarwal AN, et al. Guidelines for diagnosis and management of community- and hospital-acquired pneumonia in adults: joint ICS/NCCP(I) recommendations. Lung India. 2012;29(suppl 2):S27-S62.​​​​​​​​​​​​​​​​​​​​​Xia J, Zhang D, Xu Y, Gong M, Zhou Y, Fang X. A retrospective analysis of carbapenem-resistant Acinetobacter baumannii-mediated nosocomial pneumonia and the in vitro therapeutic benefit of cefoperazone/sulbactam. Int J Infect Dis. 2014;23:90-93.​​​​​​​Kanchanasuwan S, Kositpantawong N, Singkhamanan K, et al. Outcomes of adjunctive therapy with intravenous cefoperazone-sulbactam for ventilator-associated pneumonia due to carbapenem-resistant Acinetobacter baumannii. Infect Drug Resist. 2021;14:1255-1264.​​​​​​​Singhal T. “Rationalization of empiric antibiotic therapy” - a move towards preventing emergence of resistant infections. Indian J Pediatr. 2020;87(11):945-950.​​​​​​​Vijayganapathy S, Karthikeyan VS, Mallya A, Mythri KM, Visvanatha R, Keshavamurthy R. Antimicrobial resistance patterns in a tertiary care nephro-urology center in South India. J Integr Nephrol Androl. 2018;5:93-99.Sader HS, Carvalhaes CG, Streit JM, Castanheira M, Flamm RK. Antimicrobial activity of cefoperazone-sulbactam tested against gram-negative organisms from Europe, Asia-Pacific, and Latin America. Int J Infect Dis. 2020;91:32-37.​​​​​​​​​​​​​​Shiber S, Yahav D, Avni T, Leibovici L, Paul M. β-Lactam/β-lactamase inhibitors versus carbapenems for the treatment of sepsis: systematic review and meta-analysis of randomized controlled trials. J Antimicrob Chemother. 2015;70(1):41-47. 


Please click the Prescribing Information link to view the safety and adverse events information of MAGNEX®.
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PP-MGX-IND-0555 June 2022
Clinical & Scientific Data

About

Cefoperazone/Sulbactam: ​​​​​​​Extended coverage with β-lactamase inhibition​​​​​​

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Dosing

Recommended dosage in adult ​​​​​​and special population​​​​​​​

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Efficacy

Cefoperazone/Sulbactam is recommended as an effective and well-tolerated antibiotic

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