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Indication: Monotherapy – Sulbactam/Cefoperazone is indicated for the treatment of the following infections when caused by susceptible organisms: Respiratory tract infections, urinary tract infections (upper and lower), intra-abdominal infections, septicaemia, meningitis, skin and soft tissue infections, bone and joint infections, endometritis and other infections in the genital tract. MAGNEX® FORTE is indicated for a specific subset of patients (patients with immunocompromised febrile neutropenic cancer, patients who have undergone a bone marrow transplant).1

Clinical Efficacy

MAGNEX is effective in FN2,3
 

The clinical efficacy and tolerability of cefoperazone/sulbactam are comparable to comparator drugs in the treatment of FN: Meta-analysis outcomes

  • Overall, cefoperazone/sulbactam exhibited a treatment success rate similar to those of comparator drugs for the treatment of FN (OR, 1.03)4

Adapted from Lan SH, et al. 2020.


CI, confidence interval; FN, febrile neutropenia; OR, odds ratio.
​​​​​​​
References:​​​​​​​

Magnex. Local product document. Pfizer; 2020. Version LPDMGX042020.

​​​​​​​Lakshmaiah KC, Malabagi AS, Govindbabu, et al. Febrile neutropenia in hematological malignancies: clinical and microbiological profile and outcome in high-risk patients. J Lab Physicians. 2015;7(2):116-120.

Taj M, Farzana T, Shah T, et al. Clinical and microbiological profile of pathogens in febrile neutropenia in hematological malignancies: a single center prospective analysis. J Oncol. 2015;2015:596504.

Lan SH, Chang SP, Lai CC, Lu LC, Tang HJ. Efficacy and safety of cefoperazone-sulbactam in empiric therapy for febrile neutropenia: a systemic review and meta-analysis. Medicine (Baltimore). 2020;99(8):e19321. 


​​​​​​​Please click the Prescribing Information link to view the safety and adverse events information of MAGNEX®. 
For the use only of registered medical practitioner, or a hospital or a laboratory.​​​​​​​


PP-MGX-IND-0555 June 2022



Febrile Neutropenia

Abbreviation: 
FN, febrile neutropenia.

Reference:

1. Magnex. Local product document. Version LPDMGX042020. 

2. Gan Z, Wenjie Z, Sujie P. Clinical study of cefoperazone sodium and sulbactam sodium in the treatment of severe nosocomial lower respiratory tract infections. China Modern Medicine. 2012;23:117-118.

About

Cefoperazone/Sulbactam: ​​​​​​​Extended coverage with β-lactamase inhibition​​​​​​

Learn more


Dosing

Recommended dosage in adult ​​​​​​and special population​​​​​​​

Learn more


Safety

Explore the safety profile of cefoperazone/sulbactam​​​​​​​

Review safety profile


Clinical & Scientific Data

Cefoperazone/Sulbactam is more efficient in the treatment ​​​​​​​of infection​​​​​​​

Learn more
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These pages are not intended for patients or for members of the general public. The web pages contain promotional content. For the use only of Registered Medical Practitioners or a Hospital or a Laboratory. Full prescribing information available on request. For more details on, Who is a Registered Medical Practitioner, please visit "https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf", Page No. 39, Rule 2 part (ee), last accessed on 26th April2021.
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