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AboutAboutExtended CoveragePK and PD ProfileGood Safety ProfileGuidelines and RecommendationsDosingRecommended DosageAdultsSpecial PopulationEfficacyIntra-abdominal InfectionRisk factorClinical efficacyUrinary Tract InfectionRisk factorClinical efficacyRespiratory Tract InfectionResistance rateImpactClinical efficacyFebrile NeutropeniaRisk factorTreatmentClinical efficacySafetyClinical & Scientific DataSupport & ResourcesSupport & ResourcesClinical UpdatesPrescribing InformationVideosWebinars

Indication: Monotherapy – Sulbactam/Cefoperazone is indicated for the treatment of the following infections when caused by susceptible organisms: Respiratory tract infections, urinary tract infections (upper and lower), intra-abdominal infections, septicaemia, meningitis, skin and soft tissue infections, bone and joint infections, endometritis and other infections in the genital tract. MAGNEX® FORTE is indicated for a specific subset of patients (patients with immunocompromised febrile neutropenic cancer, patients who have undergone a bone marrow transplant).1

Risk Factor

FN is one of the most serious clinical problems in patients with haematologic malignancies and patients receiving chemotherapy2
  • FN leads to a decrease in the dose intensity of chemotherapeutic agents and poor outcomes3
     
  • An appropriate initial antibiotic can reduce mortality from 75% to <10%3
     
  • Indiscriminate use of higher antibiotics must be restricted and therapy should be tailored according to the bacterial culture3

Total Positive Blood Culture Isolates (%)4

  


FN, febrile neutropenia.​​​​​​​


References :

Magnex: Local product document. Pfizer; 2020. Version LPDMGX042020.

Karimi F, Ashrafi F, Moghaddas A, Derakhshandeh A. Management of febrile neutropenia: a description of clinical and microbiological findings by focusing on risk factors and pitfalls. J Res Pharm Pract. 2018;7(3):147-156.​​​​​​​

​​​​​​​Lakshmaiah KC, Malabagi AS, Govindbabu, et al. Febrile neutropenia in hematological malignancies: clinical and microbiological profile and outcome in high-risk patients. J Lab Physicians. 2015;7(2):116-120.

Ghosh S, Chakraborty M, Samanta S, et al. Analysis of blood stream infections, antibiograms and clinical outcomes in haematological patients with febrile neutropenia: data from a tertiary care haematology institute in India. Ann Hematol. 2021;100(2):395-403.


​​​​​​​​​​​​Please click the Prescribing Information link to view the safety and adverse events information of MAGNEX®.

For the use only of registered medical practitioner, or a hospital or a laboratory.​​​​​​​


PP-MGX-IND-0555 June 2022
Febrile Neutropenia

About

Cefoperazone/Sulbactam: ​​​​​​​Extended coverage with β-lactamase inhibition​​​​​​

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Dosing

Recommended dosage in adult ​​​​​​and special population​​​​​​​

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Safety

Explore the safety profile of cefoperazone/sulbactam​​​​​​​

Review safety profile


Clinical & Scientific Data

Cefoperazone/Sulbactam is more efficient in the treatment ​​​​​​​of infection​​​​​​​

Learn more

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For more details on, Who is a Registered Medical Practitioner*, please visit https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf , Page No. 39, Rule 2 part (ee), last accessed on 13th September 2019.
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