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Indication: Monotherapy – Sulbactam/Cefoperazone is indicated for the treatment of the following infections when caused by susceptible organisms: Respiratory tract infections, urinary tract infections (upper and lower), intra-abdominal infections, septicaemia, meningitis, skin and soft tissue infections, bone and joint infections, endometritis and other infections in the genital tract. MAGNEX® FORTE is indicated for a specific subset of patients (patients with immunocompromised febrile neutropenic cancer, patients who have undergone a bone marrow transplant).1

Treatment

Cefoperazone/Sulbactam is a good option in high-risk patients with FN

  • Gram-negative bacteria were predominant (55%), cefoperazone/sulbactam had the highest in vitro efficacy (84%) against them2
      
  • A frontline regime of cefoperazone/sulbactam and amikacin (or levofloxacin) had a sustained clinical response in 30% episodes2
      
  • Among high-risk patients with FN, in spite of a high level of resistance to antibiotics, a frontline regime containing cefoperazone/sulbactam restricted the use of imipenem and resulted in an acceptable mortality of 8%2

Adapted from Ghosh I, et al. 2012.



FN, febrile neutropenia.

References​​​​​​​ :​​​​​​​

Magnex. Local product document. Pfizer; 2020. Version LPDMGX042020.

Ghosh I, Raina V, Kumar L, et al. Profile of infections and outcome in high-risk febrile neutropenia: experience from a tertiary care cancer center in India. Med Oncol. 2012;29(2):1354-1360.


​​​​​​​Please click the Prescribing Information link to view the safety and adverse events information of MAGNEX®.
For the use only of registered medical practitioner, or a hospital or a laboratory.​​​​​​​


PP-MGX-IND-0555 June 2022
Febrile Neutropenia

Abbreviation: 
FN, febrile neutropenia.

Reference:

1. Magnex. Local product document. Version LPDMGX042020. 

2. Gan Z, Wenjie Z, Sujie P. Clinical study of cefoperazone sodium and sulbactam sodium in the treatment of severe nosocomial lower respiratory tract infections. China Modern Medicine. 2012;23:117-118.

About

Cefoperazone/Sulbactam: ​​​​​​​Extended coverage with β-lactamase inhibition​​​​​​

Learn more


Dosing

Recommended dosage in adult ​​​​​​and special population​​​​​​​

Learn more


Safety

Explore the safety profile of cefoperazone/sulbactam​​​​​​​

Review safety profile


Clinical & Scientific Data

Cefoperazone/Sulbactam is more efficient in the treatment ​​​​​​​of infection​​​​​​​

Learn more
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For more details on, Who is a Registered medical practitioner*, please visit https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf , Page No. 39, Rule 2 part (ee), last accessed on 26th April 2021.
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