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AboutAboutExtended CoveragePK and PD ProfileGood Safety ProfileGuidelines and RecommendationsDosingRecommended DosageAdultsSpecial PopulationEfficacyIntra-abdominal InfectionRisk factorClinical efficacyUrinary Tract InfectionRisk factorClinical efficacyRespiratory Tract InfectionResistance rateImpactClinical efficacyFebrile NeutropeniaRisk factorTreatmentClinical efficacySafetyClinical & Scientific DataSupport & ResourcesSupport & ResourcesClinical UpdatesPrescribing InformationVideosWebinars

Indication: Monotherapy – Sulbactam/Cefoperazone is indicated for the treatment of the following infections when caused by susceptible organisms: Respiratory tract infections, urinary tract infections (upper and lower), intra-abdominal infections, septicaemia, meningitis, skin and soft tissue infections, bone and joint infections, endometritis and other infections in the genital tract. MAGNEX® FORTE is indicated for a specific subset of patients (patients with immunocompromised febrile neutropenic cancer, patients who have undergone a bone marrow transplant).1

Clinical Efficacy

Cefoperazone/Sulbactam with 100% sensitivity is found to be the most effective drug for the therapy of UTIs: The Indian perspective

   

P. aeruginosa showed an increased resistance towards the third-generation cephalosporins and a decreased resistance towards the flouroquinolones.2

P. aeruginosa showed an increased resistance towards the third-generation cephalosporins and a decreased resistance towards the flouroquinolones.2

   

Adapted from Ahmed SM. 2012.

Imipenem, piperacillin/tazobactam and cefoperazone/sulbactam, with 100% sensitivity, and amikacin, with 87.5% sensitivity, were found to be the most effective drugs for the treatment of UTIs.2

   

Cefoperazone/Sulbactam and cefotaxime/sulbactam are equally efficacious for the treatment of CA-UTI in hospitalised patients​​​​​​

   

TitleExample Text
Rate of clinical improvement at test-of-cure visit was 87.50% and 92.00%, while microbiological cure rate was 93.75% and 84.00% with the cefoperazone/sulbactam and cefotaxime/sulbactam groups, respectively.3

   

Adapted from Makwana SP, et al. 2019.

   

Cefoperazone/Sulbactam has better efficacy compared with meropenem in gram-negative uropathogens

   

E. coli was the most common pathogen isolated, sensitive to nitrofurantoin, cefoperazone/sulbactam and aminoglycosides followed by meropenem.4

   

Adapted from Gupta P, et al. 2015

 

 

CA-UTI, catheter-associated urinary tract infection; UTI, urinary tract infection.​​​​​​​

 

References :

Magnex: Local product document. Pfizer; 2020. Version LPDMGX042020.​​​​​​​​​​​​​​Ahmed SM, Jakribettu RP, Koyakutty S, Arya B, Shakir VPA. Urinary tract infections – an overview on the prevalence and the anti-biogram of gram negative uropathogens in a tertiary care centre in North Kerala, India. J Clin Diag Res. 2012;6(7):1192-1195.​​​​​​​Makwana SP, Solanki MN, Dikshit RK. Cefoperazone + sulbactam versus cefotaxime + sulbactam combination therapy for the treatment of complicated urinary tract infections in hospitalized patients: safety and efficacy analysis. Natl J Physiol Pharm Pharmacol. 2019;9(2):187-195.​​​​​​​​​​​​​​Gupta P, Mandal J, Krishnamurthy S, Barathi D, Pandit N. Profile of urinary tract infections in paediatric patients [published correction appears in Indian J Med Res. 2015 Jun;141(6):850]. Indian J Med Res. 2015;141(4):473-477.
​​​​​​​Please click the Prescribing Information link to view the safety and adverse events information of MAGNEX®.
For the use only of registered medical practitioner, or a hospital or a laboratory.

PP-MGX-IND-0555 June 2022

Urinary Tract Infection


About

Cefoperazone/Sulbactam: ​​​​​​​Extended coverage with β-lactamase inhibition​​​​​​

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Dosing

Recommended dosage in adult ​​​​​​and special population​​​​​​​

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Safety

Explore the safety profile of cefoperazone/sulbactam​​​​​​​

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Clinical & Scientific Data

Cefoperazone/Sulbactam is more efficient in the treatment ​​​​​​​of infection​​​​​​​

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