Proportion of Patients With an ACR Response1
The percentages of tofacitinib-treated patients achieving ACR20, ACR50 and ACR70 responses in studies RA-I, IV and V are shown in the table below. Similar results were observed with studies RA II and III. In trials RA I through V, patients treated with 5 mg BID tofacitinib had higher ACR20, ACR50 and ACR70 response rates versus those treated with placebo, with or without background DMARD treatment, at Month 3 and Month 6. Higher ACR20 response rates were observed within 2 weeks compared with placebo. In the 12-month trials, ACR response rates in tofacitinib-treated patients were consistent with those at 6 and 12 months.
*N is the number of randomised and treated patients.
†NA, as data for the placebo treatment is not available beyond 3 months in studies I and V due to placebo advancement.
‡IR to at least 1 DMARD (biologic or nonbiologic) due to the lack of efficacy or toxicity.
§IR to MTX defined as the presence of sufficient residual disease activity to meet the entry criteria.
||IR to at least 1 TNF blocker due to the lack of efficacy and/or intolerance.
ACR, American College of Rheumatology; BID, twice daily; IR, inadequate responder; DMARD, disease-modifying antirheumatic drug; MTX, methotrexate; NA, not applicable; PBO, placebo; RA, rheumatoid arthritis; TNF, tumour necrosis factor.
XELJANZ® (tofacitinib citrate) is a small molecule that selectively targets the JAK pathway
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