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Efficacy & SafetyClinical Efficacy RARapid Data (ACR20)Head-to-Head Noninferiority Data (ACR50)Biologics DataClinical Efficacy PsAACR20 DataPASI75 DataEnthesitis and Dactylitis DataClinical Efficacy UC8-week EfficacyOnset of Action Data52-week EfficacyOCTAVE Study DesignSafety and TolerabilitySafety in RASafety in PsASafety in UCResources & SupportResources & SupportMaterialsVideosSummary of Prescribing Information

Results that Gives You Confidence

Proportion of Patients With an ACR Response1

    

The percentages of tofacitinib-treated patients achieving ACR20, ACR50 and ACR70 responses in studies RA-I, IV and V are shown in the table below. Similar results were observed with studies RA II and III. In trials RA I through V, patients treated with 5 mg BID tofacitinib had higher ACR20, ACR50 and ACR70 response rates versus those treated with placebo, with or without background DMARD treatment, at Month 3 and Month 6. Higher ACR20 response rates were observed within 2 weeks compared with placebo. In the 12-month trials, ACR response rates in tofacitinib-treated patients were consistent with those at 6 and 12 months.

 

   

*N is the number of randomised and treated patients. 
NA, as data for the placebo treatment is not available beyond 3 months in studies I and V due to placebo advancement. 
IR to at least 1 DMARD (biologic or nonbiologic) due to the lack of efficacy or toxicity. 
§IR to MTX defined as the presence of sufficient residual disease activity to meet the entry criteria. 
||IR to at least 1 TNF blocker due to the lack of efficacy and/or intolerance. 

   

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Learn about the XELJANZ® (tofacitinib citrate) safety profile in RA See safety data

  

  

ACR, American College of Rheumatology; BID, twice daily; IR, inadequate responder; DMARD, disease-modifying antirheumatic drug; MTX, methotrexate; NA, not applicable; PBO, placebo; RA, rheumatoid arthritis; TNF, tumour necrosis factor.

  

Reference:

Xeljanz. Local product document. Pfizer; 2022. Version LPDTOFA012022.

  

Please click the Prescribing Information link to view the safety and adverse events information of Xeljanz®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.


PP-XEL-IND-0843 22/07/22

  

Clinical Efficacy RA

About

XELJANZ® (tofacitinib citrate) is a small molecule that selectively targets the JAK pathway

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Dosing & Administration

   

Helps protect against RA, PsA and UC

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