XELJANZ® (tofacitinib citrate) delivered significant results versus placebo, even in more challenging patients with prior TNFi treatment failure1
XELJANZ® (tofacitinib citrate) significantly improved the Mayo scores in more patients who failed prior TNFi therapy versus placebo at Week 521,2
Data From the OCTAVE Sustain Maintenance Study: TNFi-failure Patients Only1,2
Adapted from Sandborn WJ, et al. 2017.
*Remission was deﬁned as a Mayo score of ≤2 with no individual subscore of >1 and rectal bleeding subscore of 0.3
†Improvement of endoscopic appearance of the mucosa was defined as a Mayo endoscopic subscore of 0 (normal or inactive disease) or 1 (erythema, decreased vascular pattern).3 To limit potential bias, evaluation of endoscopies was conducted by readers who were blinded to treatment (XELJANZ® [tofacitinib citrate] or placebo) and had no contact with patients, investigators or other individuals involved in the study.1-3
‡Sustained steroid-free remission was deﬁned as being in remission and on no corticosteroids for at least 4 weeks prior to the visit at both Weeks 24 and 52 among those in remission at maintenance baseline.1
The recommended dose is 10 mg given orally BID for induction for 8 weeks.
The recommended dose for the maintenance treatment is XELJANZ® (tofacitinib citrate) 5 mg given orally BID.4
BID, twice daily; OCTAVE, Operationally Critical Threat, Asset and Vulnerability Evaluation; TNFi, tumour necrosis factor inhibitor.
Dosing & Administration
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