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XELJANZ® delivered significant results versus placebo

XELJANZ® (tofacitinib citrate) delivered significant results versus placebo, even in more challenging patients with prior TNFi treatment failure1
 

XELJANZ® (tofacitinib citrate) significantly improved the Mayo scores in more patients who failed prior TNFi therapy versus placebo at Week 521,2
 

Data From the OCTAVE Sustain Maintenance Study: TNFi-failure Patients Only1,2

  

Adapted from Sandborn WJ, et al. 2017.

  

*Remission was defined as a Mayo score of ≤2 with no individual subscore of >1 and rectal bleeding subscore of 0.3
Improvement of endoscopic appearance of the mucosa was defined as a Mayo endoscopic subscore of 0 (normal or inactive disease) or 1 (erythema, decreased vascular pattern).3 To limit potential bias, evaluation of endoscopies was conducted by readers who were blinded to treatment (XELJANZ® [tofacitinib citrate] or placebo) and had no contact with patients, investigators or other individuals involved in the study.1-3 
Sustained steroid-free remission was defined as being in remission and on no corticosteroids for at least 4 weeks prior to the visit at both Weeks 24 and 52 among those in remission at maintenance baseline.1

  • The recommended dose is 10 mg given orally BID for induction for 8 weeks.

  • The recommended dose for the maintenance treatment is XELJANZ® (tofacitinib citrate) 5 mg given orally BID.4

Example

Example

Example

BID, twice daily; OCTAVE, Operationally Critical Threat, Asset and Vulnerability Evaluation; TNFi, tumour necrosis factor inhibitor.

References:

Sandborn WJ, Su C, Sands BE, et al. Tofacitinib as induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2017;376(18):1723-1736.Data on file. Pfizer Inc., New York, NY.Sandborn WJ, Su C, Sands BE, et al; OCTAVE Induction 1, OCTAVE Induction 2, and OCTAVE Sustain Investigators. Tofacitinib as induction and maintenance therapy for ulcerative colitis  (Supplementary Appendix). N Engl J Med. 2017;376(18):1-77.Xeljanz. Local product document. Pfizer; 2022. Version LPDTOFA012022.

   

Please click the Prescribing Information link to view the safety and adverse events information of Xeljanz®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.


PP-XEL-IND-0843 22/07/22

Clinical Efficacy in UC

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XELJANZ® (tofacitinib citrate) is a small molecule that selectively targets the JAK pathway

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Dosing & Administration

   

Helps protect against RA, PsA and UC

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These pages are not intended for patients or for members of the general public. The web pages contain promotional content. For the use only of Registered Medical Practitioners or a Hospital or a Laboratory. Full prescribing information available on request. For more details on, Who is a Registered Medical Practitioner, please visit "https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf", Page No. 39, Rule 2 part (ee), last accessed on 26th April2021.
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For more details on, Who is a Registered medical practitioner*, please visit https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf , Page No. 39, Rule 2 part (ee), last accessed on 26th April 2021.
Address: The Capital, A Wing, 1802, 18th Floor, Plot No. C-70, 'G' Block, Bandra Kurla Complex, Bandra East, Mumbai - 400051.


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