XELJANZ® (tofacitinib citrate) induction therapy* achieved rapid† induction of efficacy1,2
A significantly greater proportion of patients taking XELJANZ® (tofacitinib citrate) 10 mg BID achieved treatment end points versus placebo at Week 8 across multiple efficacy parameters1,2
Pooled Central Read Data From OCTAVE 1 and OCTAVE 2 Induction Studies1,2
Adapted from Sandborn WJ, et al. 2017.
*Two randomised, multicentre, double-blind, placebo-controlled Phase 3 studies of patients with moderate to severe UC who received XELJANZ® (tofacitinib citrate) 10 mg BID or placebo for 8 weeks.1
†Rapid induction as early as Week 2 in OCTAVE 1 and OCTAVE 2 studies.
‡Remission was stringently deﬁned as a total Mayo score of ≤2, with no individual subscore of >1 and a rectal bleeding subscore of 0.1.
§Improvement of endoscopic appearance of the mucosa was deﬁned as a Mayo endoscopic subscore of 0 (normal or inactive disease) or 1 (erythema, decreased vascular pattern).
IIClinical response was deﬁned as a decrease from baseline in the Mayo score of ≥3 points and ≥30%, with an accompanying decrease in the subscore for rectal bleeding of ≥1 point or absolute subscore for rectal bleeding of 0 or 1.1 The recommended dose is 10 mg given orally BID for induction for 8 weeks.3 The recommended dose for the maintenance treatment is XELJANZ® (tofacitinib citrate) 5 mg given orally BID.
BID, twice daily; OCTAVE, Operationally Critical Threat, Asset and Vulnerability Evaluation; TNFi, tumour necrosis factor inhibitor; UC, ulcerative colitis.
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