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Improvement in Stool Frequency

XELJANZ® (tofacitinib citrate) delivered a rapid reduction in stool frequency in as early as 2 weeks1

   

XELJANZ® (tofacitinib citrate) 10 mg BID achieved a statistically significant reduction in the stool frequency subscore* versus placebo2

   

Pooled Data From OCTAVE 1 and OCTAVE 2 Induction Studies2

   

   

Adapted from Data on file. Pfizer Inc.

   

P values obtained from linear mixed-effects model. Efficacy data are full analysis sets with observed cases.1

   

*The Mayo stool frequency subscore is a patient-reported measure of disease activity that ranges from 0 to 3 (0 = normal, 1 = 1-2 stools/day more than normal, 2 = 3-4 stools/day more than normal, 3 = >5 stools/day more than normal or 1).3

   

XELJANZ® (tofacitinib citrate) delivered a rapid reduction in rectal bleeding in as early as 2 weeks1

   

XELJANZ 10 mg BID significantly reduced the rectal bleeding subscore* versus placebo

   

Pooled Data From OCTAVE 1 and OCTAVE 2 Induction Studies2

   

Adapted from Data on file. Pfizer Inc.

P values obtained from linear mixed-effects model. Efficacy data are full analysis sets with observed cases.1

*The Mayo rectal bleeding subscore is a patient-reported measure of disease activity that ranges from 0 to 3 (0 = none, 1 = streaks of blood visible with stool in less than half the time, 2 = blood visible in stool in more than half the time, 3 = blood passed without stool).3

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 Do you want to see sustained efficacy data for XELJANZ® (tofacitinib citrate)? Learn more

  

  

BID, twice daily; LS, least square; OCTAVE, Operationally Critical Threat, Asset and Vulnerability Evaluation.

  

References:

Sandborn WJ, Su C, Sands BE, et al; OCTAVE Induction 1, OCTAVE Induction 2, and OCTAVE Sustain Investigators. tofacitinib as induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2017;376(18):1723-1736.Data on file. Pfizer Inc., New York, NY.Schroeder KW, Tremaine WJ, Ilstrup DM. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. N Engl J Med. 1987;317(26):1625-1629.

  

Please click the Prescribing Information link to view the safety and adverse events information of Xeljanz®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

PP-XEL-IND-0843 22/07/22
Clinical Efficacy in UC

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XELJANZ® (tofacitinib citrate) is a small molecule that selectively targets the JAK pathway

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Dosing & Administration

   

Helps protect against RA, PsA and UC

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These pages are not intended for patients or for members of the general public. The web pages contain promotional content. For the use only of Registered Medical Practitioners or a Hospital or a Laboratory. Full prescribing information available on request. For more details on, Who is a Registered Medical Practitioner, please visit "https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf", Page No. 39, Rule 2 part (ee), last accessed on 26th April2021.
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