Identify ZINFORO^® Patient With cSSTI

How do you identify your ZINFORO^® patients with cSSTI?^1-5,*
 

Zinforo^® cSSTI patient profiles^6,7,*

Patient 1: Patient with diabetes having a cSSTI

A 62-year-old female with diabetes presents with deep and extensive cellulitis on the right leg that extends from the mid-calf to the ankle.

Patient presentation, history and risk factors

• Tender, erythematous, non-raised skin lesions
   
• Rapid spread of infection over the past 24 hours
   
• Patient weight = 102 kg
   
• BMI = 36 kg/m²
   
• Elevated blood cholesterol
   
• HbA1c = 7.4%
   
• History of smoking
   
• Nursing home resident
   
• Recent use of an old cephalosporin for a skin lesion 3 weeks ago

Patient 2: Patient with cSSTI having renal insufficiency^†

A 67-year-old male presents with a painful, fluctuant and gluteal abscess.

Patient presentation, history and risk factors:

• Rapidly spreading infection
   
• Patient is deteriorating; may be required to be moved to the ICU in the next 24 hours
   
• Severe renal insufficiency (CrCl at hospital admission: 17 mL/min)
   
• CrCl falling rapidly
   
• History of renal disease
   
• History of prior antibiotic use

Please note: The examples described here are not of actual patients, but fictitious representations of scenarios for which ZINFORO^® could be considered.

*There is no experience with Zinforo^® in the treatment of cSSTI in the following patient groups:
The immunocompromised, patients with severe sepsis/septic shock, necrotising fasciitis, perirectal abscess and patients with third-degree and extensive burns. There is limited experience in treating patients with diabetic foot infections. Caution is advised when treating such patients.^8
†Zinforo^® is primarily excreted by the kidneys and the dose should be reduced in patients with moderate to severe renal insufficiency.⁸

CAP, community-acquired pneumonia; CrCl, creatinine clearance; cSSTI, complicated skin and soft tissue infection; BMI, body mass index; HbA1c, haemoglobin A1c; ICU, intensive care unit; PVD, peripheral vascular disease.

References: