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AboutUnmet NeedCommunity-acquired PneumoniaComplicated Skin & Soft Tissue InfectionsMode of ActionVideoCommunity-acquired PneumoniaComplicated Skin & Soft Tissue InfectionsPatient ProfilesProfiles of Patients With CAPIdentify ZINFORO® Patient With CAPProfiles of Patients With cSSTIIdentify ZINFORO® Patient With cSSTIDosingRecommended Dosing ScheduleSimple DosingRenal AdjustmentEfficacyCommunity-acquired PneumoniaClinical Efficacy: Proven Clinical EfficacyClinical Efficacy: Evidence of Rapid ResponsePivotal Clinical StudiesMicrobiology: Optimising OutcomesMicrobiology: CoverageMicrobiology: Low MIC ValuesComplicated Skin & Soft Tissue InfectionsClinical Efficacy: Proven Clinical EfficacyClinical Efficacy: Evidence of Rapid ResponsePivotal Clinical StudiesMicrobiology: Optimising OutcomesMicrobiology: CoverageMicrobiology: Low MIC ValuesSafetySafetyKey safety featuresLow Incidence of Discontinuation in CAPLow Incidence of Discontinuation in cSSTIClinical & Scientific Data Clinical & Scientific Data Efficacy in the Treatment of CAPClinical Cure Rates Against Relevant PathogensClinical Cure Rates Across Patient SubgroupsDemonstrated Superiority to CeftriaxoneEarly Clinical ResponseReal-world Efficacy in Elderly PatientsConsistent Clinical Cure Rates in cSSTIClinical Cure Rates in Common Causative PathogensClinical Cure Rates in Patients With ComorbiditiesEarly Clinical EfficacyReal-life Efficacy in Clinical PracticeSupport & ResourcesSupport & ResourcesClinical updatesPrescribing InformationVideosWebinars


Profiles of Patients With CAP

ZINFORO® (ceftaroline fosamil): Profiles of patients with CAP

Identifying a patient with CAP who may benefit from ZINFORO®
In patients with CAP, initial antimicrobial treatment modification occurs in >25% of patients and is frequently the result of insufficient response or treatment failure.1,*

   

George, a 70-year-old nursing home resident, presents with fever, cough and sputum production.

Severity
  • PORT Score IV (severe)
  • 70-year-old male
  • RR >30 breaths/minute
  • Temperature >40°C
  • Nursing home resident
History/Comorbidities
  • Structural lung disease
  • History of smoking
Risk factors for difficult-to-treat infection
  • Age >65 years
  • Recurrent infection (hospitalised for pneumonia 3 months ago)
 
Marco presents with fever, cough and pleuritic chest pain and there has been no improvement with ceftriaxone.

Severity
  • PORT Score IV (severe)
  • 78-year-old male
  • Chronic renal disease
  • Pulse >125 bpm
  • RR >30 breaths/minute
  • No clinical improvement within 72 hours of ceftriaxone initiation
History/Comorbidities
  • Renal insufficiency
  • Recent alcoholism
Risk factors for difficult-to-treat infection
  • Age >65 years
  • Medical comorbidities
  • Alcoholism
 
Marie presents with fever, dyspnoea and cough.                                                                              

Severity
  • PORT Score III (moderate)
  • 56-year-old female
  • PO2 <90% (upon admission)
  • Glucose >250
  • Increasing oxygen requirements to maintain oxygen saturation
  • May require ICU in the next 24 hours
History/Comorbidities
  • Asthma
  • Diabetes
Risk factors for difficult-to-treat infection
  • Recent antibiotic exposure for URTI within previous 3 months

Severity
  • PORT Score IV (severe)
  • 78-year-old male
  • Chronic renal disease
  • Pulse >125 bpm
  • RR >30 breaths/minute
  • No clinical improvement within 72 hours of ceftriaxone initiation
History/Comorbidities
  • Renal insufficiency
  • Recent alcoholism
Risk factors for difficult-to-treat infection
  • Age >65 years
  • Medical comorbidities
  • Alcoholism
 



​​​​​Please note: The examples described here are not of actual patients, but fictitious representations of scenarios for which ZINFORO® (ceftaroline fosamil) could be considered.

Refer to the local product document for further information on ZINFORO®.2

*There is no experience with ZINFORO® (ceftaroline fosamil) in the treatment of CAP in the following patient groups: The immunocompromised, patients with severe sepsis/septic shock and severe underlying lung disease, patients with PORT risk Class V, and/or CAP requiring ventilation at presentation, CAP due to MRSA and patients requiring intensive care; the available clinical data cannot substantiate efficacy against PNSP.2

bpm, beats per minute; cSSTI, complicated skin and soft tissue infection; CAP, community-acquired pneumonia; ICU, intensive care unit; MRSA, methicillin-resistant Staphylococcus aureus; PNSP, penicillin-nonsusceptible pneumococci; PO2, partial pressure of oxygen; PORT, Pneumonia Patient Outcomes Research Team; RR, respiratory rate; URTI, upper respiratory tract infection.


References:

Blasi F, Garau J, Medina J, et al. Current management of patients hospitalized with community-acquired pneumonia across Europe: outcomes from REACH. Respir Res. 2013;14(1):44.Zinforo. Local product document. Pfizer; 2021. Version LPDZIN072021.


​​​​​Please click the Prescribing Information link to view the safety and adverse events information of ZINFORO®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.
​​​​​​​
PP-ZFO-IND-0417 June 2022

Patient Profiles​​​​​​​

Example

Dosing

Simple dosing with a flexible infusion time

Learn moreLoading


Efficacy

Proven clinical efficacy in patients with
CAP and cSSTI

Review efficacy profile


Safety

Safety profile consistent with other cephalosporins

Review safety profile


Clinical & Scientific Data

​​​​ZINFORO® in the treatment of CAP and cSSTI​​​​​​

Learn more
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