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AboutUnmet NeedCommunity-acquired PneumoniaComplicated Skin & Soft Tissue InfectionsMode of ActionVideoCommunity-acquired PneumoniaComplicated Skin & Soft Tissue InfectionsPatient ProfilesProfiles of Patients With CAPIdentify ZINFORO® Patient With CAPProfiles of Patients With cSSTIIdentify ZINFORO® Patient With cSSTIDosingRecommended Dosing ScheduleSimple DosingRenal AdjustmentEfficacyCommunity-acquired PneumoniaClinical Efficacy: Proven Clinical EfficacyClinical Efficacy: Evidence of Rapid ResponsePivotal Clinical StudiesMicrobiology: Optimising OutcomesMicrobiology: CoverageMicrobiology: Low MIC ValuesComplicated Skin & Soft Tissue InfectionsClinical Efficacy: Proven Clinical EfficacyClinical Efficacy: Evidence of Rapid ResponsePivotal Clinical StudiesMicrobiology: Optimising OutcomesMicrobiology: CoverageMicrobiology: Low MIC ValuesSafetySafetyKey safety featuresLow Incidence of Discontinuation in CAPLow Incidence of Discontinuation in cSSTIClinical & Scientific Data Clinical & Scientific Data Efficacy in the Treatment of CAPClinical Cure Rates Against Relevant PathogensClinical Cure Rates Across Patient SubgroupsDemonstrated Superiority to CeftriaxoneEarly Clinical ResponseReal-world Efficacy in Elderly PatientsConsistent Clinical Cure Rates in cSSTIClinical Cure Rates in Common Causative PathogensClinical Cure Rates in Patients With ComorbiditiesEarly Clinical EfficacyReal-life Efficacy in Clinical PracticeSupport & ResourcesSupport & ResourcesClinical updatesPrescribing InformationVideosWebinars


Profiles of Patients With cSSTI

ZINFORO® (ceftaroline fosamil): Profiles of patients with cSSTI
 

Identify patients with cSSTI who may benefit from ZINFORO®

In patients with cSSTI, initial antimicrobial therapy failure is associated with 4 to 11 days longer
hospital stays and 4 to 12× higher mortality.1-3

   

Laura, a 71-year-old female, with diabetes and cellulitis, presents with tender erythematous, non-raised lesions.*

Severity
  • Deep and extensive cellulitis on the right leg that extends from the mid-calf to the ankle (~275 cm2)
  • Signs of systemic inflammatory response – Temperature >38°C
  • Rapid spread of erythema over past 24 hours
History/Comorbidities
  • History of smoking
  • Type 2 insulin-dependent diabetes HbA1c = 7.4%
Risk factors for difficult-to-treat infection
  • Nursing home resident
  • Comorbidities associated with impaired immune response (DM)
 
Martin, a 44-year-old male, readmitted to the hospital following inguinal hernia repair with purulent drainage from incision and localised pain.*

Severity
  • Signs of systemic inflammatory response

    - Temperature >38°C

    -  Heart rate >90 bpm
History/Comorbidities
  • History of depression (currently controlled by medication)

    - Obese

    - Weight = 132 kg

    - BMI = 37 kg/m2
Risk factors for difficult-to-treat infection
  • MRSA colonisation identified during admission screening for surgery
 
Mark, a 67-year-old male, admitted to the emergency room with a painful and fluctuant gluteal abscess.*

Severity
  • Abscess area of 12 cm2 , with a 95 cm2 surrounding cellulitis
  • Rapidly spreading infection Signs of systemic inflammatory response

    - Temperature >38°C

    - Heart rate >90 bpm

    - RR >20/min
  • May be required to be moved to the ICU in the next 24 hours
History/Comorbidities
  • Chronic renal impairment

    - CrCl at hospital admission = 17 mL/min
Risk factors for difficult-to-treat infection
  • Immunocompromised as a result of comorbid chronic renal disease
  • Treatment with fluoroquinolone within 6 months for UTI
 



Please note: The examples described here are not actual patients, but fictitious representations of scenarios for which ZINFORO® could be considered.

*Refer to the local product document for further information on Zinforo®.4

​​​​​​​
BMI, body mass index; bpm, beats per minute; CAP, community-acquired pneumonia; CrCl, creatinine clearance; cSSTI, complicated skin and soft tissue infection; DM, diabetes mellitus; HbA1c, haemoglobin A1c; ICU, intensive care unit; MRSA, methicillin-resistant Staphylococcus aureus; RR, respiratory rate; UTI, urinary tract infection.​​​​​​​
​​​​​​​

References:

Berger A, Oster G, Edelsberg J, Huang X, Weber DJ. Initial treatment failure in patients with complicated skin and skin structure infections. Surg Infect (Larchmt). 2013;14(3):304-312.Edelsberg J, Berger A, Weber DJ, Mallick R, Kuznik A, Oster G. Clinical and economic consequences of failure of initial antibiotic therapy for hospitalized patients with complicated skin and skin-structure infections. Infect Control Hosp Epidemiol. 2008;29(2):160-169.Ostermann H, Blasi F, Medina J, et al. Resource use in patients hospitalized with complicated skin and soft tissue infections in Europe and analysis of vulnerable groups: the REACH study. J Med Econ. 2014;17(10):719-729.Zinforo. Local product document. Pfizer; 2021. Version LPDZIN072021.


​​​​​Please click the Prescribing Information link to view the safety and adverse events information of ZINFORO®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.
​​​​​​​
PP-ZFO-IND-0417 June 2022

Patient Profiles​​​​​​​

Example

Dosing

Simple dosing with a flexible infusion time

Learn moreLoading


Efficacy

Proven clinical efficacy in patients with
CAP and cSSTI

Review efficacy profile


Safety

Safety profile consistent with other cephalosporins

Review safety profile


Clinical & Scientific Data

​​​​ZINFORO® in the treatment of CAP and cSSTI​​​​​​

Learn more
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For more details on, Who is a Registered Medical Practitioner*, please visit https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf , Page No. 39, Rule 2 part (ee), last accessed on 13th September 2019.
​​​​​​​Address: The Capital, A Wing, 1802, 18th Floor, Plot No. C-70, 'G' Block, Bandra Kurla Complex, Bandra East, Mumbai - 400051.


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