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AboutUnmet NeedCommunity-acquired PneumoniaComplicated Skin & Soft Tissue InfectionsMode of ActionVideoCommunity-acquired PneumoniaComplicated Skin & Soft Tissue InfectionsPatient ProfilesProfiles of Patients With CAPIdentify ZINFORO® Patient With CAPProfiles of Patients With cSSTIIdentify ZINFORO® Patient With cSSTIDosingRecommended Dosing ScheduleSimple DosingRenal AdjustmentEfficacyCommunity-acquired PneumoniaClinical Efficacy: Proven Clinical EfficacyClinical Efficacy: Evidence of Rapid ResponsePivotal Clinical StudiesMicrobiology: Optimising OutcomesMicrobiology: CoverageMicrobiology: Low MIC ValuesComplicated Skin & Soft Tissue InfectionsClinical Efficacy: Proven Clinical EfficacyClinical Efficacy: Evidence of Rapid ResponsePivotal Clinical StudiesMicrobiology: Optimising OutcomesMicrobiology: CoverageMicrobiology: Low MIC ValuesSafetySafetyKey safety featuresLow Incidence of Discontinuation in CAPLow Incidence of Discontinuation in cSSTIClinical & Scientific Data Clinical & Scientific Data Efficacy in the Treatment of CAPClinical Cure Rates Against Relevant PathogensClinical Cure Rates Across Patient SubgroupsDemonstrated Superiority to CeftriaxoneEarly Clinical ResponseReal-world Efficacy in Elderly PatientsConsistent Clinical Cure Rates in cSSTIClinical Cure Rates in Common Causative PathogensClinical Cure Rates in Patients With ComorbiditiesEarly Clinical EfficacyReal-life Efficacy in Clinical PracticeSupport & ResourcesSupport & ResourcesClinical updatesPrescribing InformationVideosWebinars


Complicated Skin & Soft Tissue Infections

Outlook for patients with cSSTI worldwide
 

ZINFORO® offers an efficacious and potent treatment for your patients with cSSTI.1-5

  • Consistently active against common causative pathogens, including MRSA
     
  • Well-tolerated and efficacious treatment for most patients, including those with comorbidities



Inadequacy of first-line treatment

Around 40% of patients with cSSTI caused by mixed pathogens received inappropriate initial antimicrobial agents.9,11

Failure of therapy

Inappropriate initial therapy may result in poor therapy outcome. Initial therapy failure is associated with higher mortality, prolonged hospitalisation and consequent increased cost burden.11

Day 3 non-response rates
​​​​
In a retrospective cohort analysis of adult patients, it was observed that non-response rates at Day 3 among patients with cSSTI receiving empiric therapy with broad-spectrum antibiotics were high.9

Longer duration of hospitalisation and antibiotic treatment and higher costs

In a retrospective cohort analysis of adult patients, it was observed that non-response to initial antibiotic therapy was associated with an overall10:

  • 5.4-day increase in hospital stays
     
  • 3.7-day increase in the duration of antibiotic administration​​​​​​​
    ​​​​​​​


*Initial antibiotic treatment modification
This is defined as the need for a change in the initial antibiotic treatment due to insufficient response, adverse reaction, interaction with other drugs, non-suitability of the initial antibiotic based on the results of microbiological tests, or changes to the antibiotic therapy or addition of further agents, alone or in combination. The presence of comorbidities is associated with higher rates of initial treatment modification in patients with cSSTI.6

Broad-spectrum antibiotics included vancomycin, cefazolin, piperacillin-tazobactam and ampicillin-sulbactam.10
The study does not include data specific to ZINFORO®. The study had the inherent limitations associated with a retrospective chart review because data were initially collected for clinical rather than research purposes. Hence, certain information may have been absent, incomplete or missed by data abstractors.

cSSTI, complicated skin and soft tissue infection; CAP, community-acquired pneumonia; MRSA, methicillin-resistant Staphylococcus aureus.

 


References:

Garrison MW, Kawamura NM, Wen MM. Ceftaroline fosamil: a new cephalosporin active against resistant Gram-positive organisms including MRSA. Expert Rev Anti Infect Ther. 2012;10(suppl 10):1087-1103.Casapao AM, Davis SL, Barr VO, et al. Large retrospective evaluation of the effectiveness and safety of ceftaroline fosamil therapy. Antimicrob Agents Chemother. 2014;58(suppl 5):2541-2546.Corey GR, Wilcox M, Talbot GH, et al. Integrated analysis of CANVAS 1 and 2: phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infection. Clin Infect Dis. 2010;51(suppl 6):641-650.Santos PD, Davis A, Jandourek A, Smith A, David Friedland H. Ceftaroline fosamil and treatment of acute bacterial skin and skin structure infections: CAPTURE study experience. J Chemother. 2013;25(suppl 6):341-346.Stein GE, Wallace S, Jandourek A, et al. Ceftaroline fosamil for treatment of cSSTI due to Staphylococcus aureus with vancomycin MICs of 1.5 to 2 mg/L: CAPTURE Study Experience. Poster presented in ESCMID. Accessed on April 26 2022. https://www.escmid.org/escmid_publications/ escmid_elibrary/material/?mid=16017.Garau J, Ostermann H, Medina J, et al. Current management of patients hospitalized with complicated skin and soft tissue infections across Europe (2010-2011): assessment of clinical practice patterns and real-life effectiveness of antibiotics from the REACH study. Clin Microbiol Infect.2013;19(suppl 9):E377-E385.Dryden MS. Complicated skin and soft tissue infection. J Antimicrob Chemother. 2010;65(suppl 3):iii35-iii44.Edelsberg J, Berger A, Weber DJ, Mallick R, Kuznik A, Oster G. Clinical and economic consequences of failure of initial antibiotic therapy for hospitalized patients with complicated skin and skin-structure infections. Infect Control Hosp Epidemiol. 2008;29(suppl 2):160-169.Zilberberg MD, Shorr AF, Micek ST, et al. Epidemiology and outcomes of hospitalizations with complicated skin and skin-structure infections: implications of healthcare-associated infection risk factors. Infect Control Hosp Epidemiol. 2009;30(suppl 12):1203-1210.Amara S, Adamson RT, Lew I, Huang X. Clinical response at Day 3 of therapy and economic outcomes in hospitalized patients with acute bacterial skin and skin structure infection (ABSSSI). Curr Med Res Opin. 2013;29(suppl 7):869-877.Kaye KS, Petty LA, Shorr AF, Zilberberg MD. Current Epidemiology, Etiology, and Burden of Acute Skin Infections in the United States. Clin Infect Dis. 2019;68(suppl 3):S193-S199.


​​​​​Please click the Prescribing Information link to view the safety and adverse events information of ZINFORO®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.
​​​​​​​
PP-ZFO-IND-0417 June 2022

Unmet Need

Example

Example


Dosing

Simple dosing with a flexible infusion time

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Efficacy

Proven clinical efficacy in patients with
CAP and cSSTI

Review efficacy profile


Safety

Safety profile consistent with other cephalosporins

Review safety profile


Clinical & Scientific Data

​​​​ZINFORO® in the treatment of CAP and cSSTI​​​​​​

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