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AboutUnmet NeedCommunity-acquired PneumoniaComplicated Skin & Soft Tissue InfectionsMode of ActionVideoCommunity-acquired PneumoniaComplicated Skin & Soft Tissue InfectionsPatient ProfilesProfiles of Patients With CAPIdentify ZINFORO® Patient With CAPProfiles of Patients With cSSTIIdentify ZINFORO® Patient With cSSTIDosingRecommended Dosing ScheduleSimple DosingRenal AdjustmentEfficacyCommunity-acquired PneumoniaClinical Efficacy: Proven Clinical EfficacyClinical Efficacy: Evidence of Rapid ResponsePivotal Clinical StudiesMicrobiology: Optimising OutcomesMicrobiology: CoverageMicrobiology: Low MIC ValuesComplicated Skin & Soft Tissue InfectionsClinical Efficacy: Proven Clinical EfficacyClinical Efficacy: Evidence of Rapid ResponsePivotal Clinical StudiesMicrobiology: Optimising OutcomesMicrobiology: CoverageMicrobiology: Low MIC ValuesSafetySafetyKey safety featuresLow Incidence of Discontinuation in CAPLow Incidence of Discontinuation in cSSTIClinical & Scientific Data Clinical & Scientific Data Efficacy in the Treatment of CAPClinical Cure Rates Against Relevant PathogensClinical Cure Rates Across Patient SubgroupsDemonstrated Superiority to CeftriaxoneEarly Clinical ResponseReal-world Efficacy in Elderly PatientsConsistent Clinical Cure Rates in cSSTIClinical Cure Rates in Common Causative PathogensClinical Cure Rates in Patients With ComorbiditiesEarly Clinical EfficacyReal-life Efficacy in Clinical PracticeSupport & ResourcesSupport & ResourcesClinical updatesPrescribing InformationVideosWebinarsExplore Materials

Clinical Cure Rates Across Patient Subgroups

Consistent clinical cure rates were demonstrated across patient subgroups1,2
 

Microbiological response (ME population)1:

  • ZINFORO®: 87.0% of patients (n=134/154)
     
  • Ceftriaxone 1 g: 81.0% of patients (n=119/147)

Clinical cure rates at TOC1:

  • ZINFORO®: 84.3% of patients (n=387/459)
     
  • Ceftriaxone 1 g: 77.7% of patients (n=349/449)

FOCUS 1 and FOCUS 2 Integrated Analysis1

  

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Adapted from File T, et al. 2010.

  


FOCUS, ceFtarOline Community-acquired pneUmonia trial versuS ceftriaxone in hospitalised patients; ME, microbiologically evaluable; PORT, Pneumonia Patient Outcomes Research Team; TOC, test of cure.
 

References:

File TM Jr, Low DE, Eckburg PB, et al. Integrated analysis of FOCUS 1 and FOCUS 2: randomized, doubled-blinded, multicenter phase 3 trials of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in patients with community-acquired pneumonia [published correction appears in Clin Infect Dis. 2011 Apr 1;52(7):967]. Clin Infect Dis. 2010;51(suppl 12):1395-1405.Shorr AF, Kollef M, Eckburg PB, Llorens L, Friedland HD. Assessment of ceftaroline fosamil in the treatment of community-acquired bacterial pneumonia due to Streptococcus pneumoniae: insights from two randomized trials. Diagn Microbiol Infect Dis. 2013;75(suppl 3):298-303.


​​​​​Please click the Prescribing Information link to view the safety and adverse events information of ZINFORO®.
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PP-ZFO-IND-0417 June 2022


About

Fifth-generation cephalosporin with broad coverage

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Dosing

Simple dosing with a flexible infusion time

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Safety

Safety profile consistent with other cephalosporins

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Clinical & Scientific Data

​​​​ZINFORO® in the treatment of CAP and cSSTI​​​​​​

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