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AboutUnmet NeedCommunity-acquired PneumoniaComplicated Skin & Soft Tissue InfectionsMode of ActionVideoCommunity-acquired PneumoniaComplicated Skin & Soft Tissue InfectionsPatient ProfilesProfiles of Patients With CAPIdentify ZINFORO® Patient With CAPProfiles of Patients With cSSTIIdentify ZINFORO® Patient With cSSTIDosingRecommended Dosing ScheduleSimple DosingRenal AdjustmentEfficacyCommunity-acquired PneumoniaClinical Efficacy: Proven Clinical EfficacyClinical Efficacy: Evidence of Rapid ResponsePivotal Clinical StudiesMicrobiology: Optimising OutcomesMicrobiology: CoverageMicrobiology: Low MIC ValuesComplicated Skin & Soft Tissue InfectionsClinical Efficacy: Proven Clinical EfficacyClinical Efficacy: Evidence of Rapid ResponsePivotal Clinical StudiesMicrobiology: Optimising OutcomesMicrobiology: CoverageMicrobiology: Low MIC ValuesSafetySafetyKey safety featuresLow Incidence of Discontinuation in CAPLow Incidence of Discontinuation in cSSTIClinical & Scientific Data Clinical & Scientific Data Efficacy in the Treatment of CAPClinical Cure Rates Against Relevant PathogensClinical Cure Rates Across Patient SubgroupsDemonstrated Superiority to CeftriaxoneEarly Clinical ResponseReal-world Efficacy in Elderly PatientsConsistent Clinical Cure Rates in cSSTIClinical Cure Rates in Common Causative PathogensClinical Cure Rates in Patients With ComorbiditiesEarly Clinical EfficacyReal-life Efficacy in Clinical PracticeSupport & ResourcesSupport & ResourcesClinical updatesPrescribing InformationVideosWebinars

Clinical Cure Rates in Common Causative Pathogens

Consistent clinical cure rates in common causative pathogens of cSSTI, including MRSA1-5

 

Zinforo® demonstrated microbiological response and clinical cure rates at TOC (CANVAS 1 and CANVAS 2 integrated analysis).1

Microbiological response rates (ME population) at TOC1

  • ZINFORO®: 92.3% of patients (n=432/468)
     
  • Vancomycin + Aztreonam: 93.7% of patients (n=418/446)

Clinical cure rates against S. aureus (ME population) at TOC1:

  • ZINFORO®: 93.1% of patients (n=352/378)
     

  • Vancomycin + Aztreonam: 94.4% of patients (n=336/356)

CANVAS 1 and CANVAS 2 integrated analysis (ME population)1-3,*
 

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Adapted from Corey G, et al. 2010.​​​​​​​


*Zinforo® does not cover against P. aeruginosa. Like all other cephalosporins, Zinforo® is not active against ESBL-producing strains.1,4


​​​​​​​CANVAS, CeftAroliNe fosamil versus VAncomycin in Skin and skin structure infection; cSSTI, complicated skin and soft tissue infection; ESBL, extended spectrum beta-lactamase; ME, microbiologically evaluable; MRSA, methicillin-resistant Staphylococcus aureus; q12h, every 12 hours; TOC, test of cure.


References:

Corey GR, Wilcox M, Talbot GH, et al. Integrated analysis of CANVAS 1 and 2: phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infection. Clin Infect Dis. 2010;51(suppl 6):641-650.
Corey GR, Wilcox MH, Talbot GH, et al. CANVAS 1: the first Phase III, randomized, double-blind study evaluating ceftaroline fosamil for the treatment of patients with complicated skin and skin structure infections. J Antimicrob Chemother. 2010;65(suppl 4):iv41-iv51.Wilcox MH, Corey GR, Talbot GH, et al. CANVAS 2: the second Phase III, randomized, double-blind study evaluating ceftaroline fosamil for the treatment of patients with complicated skin and skin structure infections. J Antimicrob Chemother. 2010;65(suppl 4):iv53-iv65.Zinforo. Local product document. Pfizer; 2021. Version LPDZIN072021.
Friedland HD, O'Neal T, Biek D, et al. CANVAS 1 and 2: analysis of clinical response at day 3 in two phase 3 trials of ceftaroline fosamil versus vancomycin plus aztreonam in treatment of acute bacterial skin and skin structure infections. Antimicrob Agents Chemother. 2012;56(suppl 5):2231-2236.


​​​​​Please click the Prescribing Information link to view the safety and adverse events information of ZINFORO®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.
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PP-ZFO-IND-0417 June 2022

Clinical & scientific data


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Fifth-generation cephalosporin with broad coverage

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Dosing

Simple dosing with a flexible infusion time

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Safety

Safety profile consistent with other cephalosporins

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Clinical & Scientific Data

​​​​ZINFORO® in the treatment of CAP and cSSTI​​​​​​

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