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AboutUnmet NeedCommunity-acquired PneumoniaComplicated Skin & Soft Tissue InfectionsMode of ActionVideoCommunity-acquired PneumoniaComplicated Skin & Soft Tissue InfectionsPatient ProfilesProfiles of Patients With CAPIdentify ZINFORO® Patient With CAPProfiles of Patients With cSSTIIdentify ZINFORO® Patient With cSSTIDosingRecommended Dosing ScheduleSimple DosingRenal AdjustmentEfficacyCommunity-acquired PneumoniaClinical Efficacy: Proven Clinical EfficacyClinical Efficacy: Evidence of Rapid ResponsePivotal Clinical StudiesMicrobiology: Optimising OutcomesMicrobiology: CoverageMicrobiology: Low MIC ValuesComplicated Skin & Soft Tissue InfectionsClinical Efficacy: Proven Clinical EfficacyClinical Efficacy: Evidence of Rapid ResponsePivotal Clinical StudiesMicrobiology: Optimising OutcomesMicrobiology: CoverageMicrobiology: Low MIC ValuesSafetySafetyKey safety featuresLow Incidence of Discontinuation in CAPLow Incidence of Discontinuation in cSSTIClinical & Scientific Data Clinical & Scientific Data Efficacy in the Treatment of CAPClinical Cure Rates Against Relevant PathogensClinical Cure Rates Across Patient SubgroupsDemonstrated Superiority to CeftriaxoneEarly Clinical ResponseReal-world Efficacy in Elderly PatientsConsistent Clinical Cure Rates in cSSTIClinical Cure Rates in Common Causative PathogensClinical Cure Rates in Patients With ComorbiditiesEarly Clinical EfficacyReal-life Efficacy in Clinical PracticeSupport & ResourcesSupport & ResourcesClinical updatesPrescribing InformationVideosWebinars

Early Clinical Response

ZINFORO® may be associated with early clinical response at Day 41,*
 

In an integrated retrospective subgroup analysis of FOCUS 1 and FOCUS 2, ZINFORO® had a numerically higher clinical response rate than ceftriaxone at Day 4.1,‡

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Similarly, Day 4 clinical response rates associated with S. pneumoniae infections were1,‡:

*This was shown not to be statistically significant.
ZINFORO® may be associated with early clinical response, based on the clinical stability and symptom improvement criteria.1
Clinical stability was defined according to the Infectious Diseases Society of America/American Thoracic Society guidelines as temperature ≤37.8 °C, heart rate ≤100 bpm, respiratory rate ≤24 breaths/min, systolic blood pressure ≥90 mm Hg, oxygen saturation ≥90% and absence of confusion/disorientation.1
Clinical improvement was defined as an improvement of at least 1 of 4 symptoms present at baseline (i.e. cough, dyspnoea, pleuritic chest pain and sputum production) with worsening of none. Patients who did not meet both the clinical stability and clinical improvement criteria or who were considered clinical failures by investigators at the EOT visit in those cases in which the EOT visit occurred on Day 4 were considered non-responders on Day 4.1
Superiority cannot be concluded based on this retrospective integrated analysis because this was neither a pre-planned analysis nor a superiority seen in an individual study.

ATS, American Thoracic Society; CAP, community-acquired pneumonia; bpm, beats per minute; EOT, end of treatment; FOCUS, ceFtarOline Community-acquired pneUmonia trial versuS ceftriaxone in hospitalised patients; IDSA, Infectious Diseases Society of America; RR, respiratory rate.

Reference:

Eckburg PB, Friedland H, Llorens L. et al. Day 4 clinical response of ceftaroline fosamil versus ceftriaxone for community-acquired bacterial pneumonia. Infect Dis Clin Pract. 2012;20:254-260.


​​​​​Please click the Prescribing Information link to view the safety and adverse events information of ZINFORO®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.
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PP-ZFO-IND-0417 June 2022


About

Fifth-generation cephalosporin with broad coverage

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Dosing

Simple dosing with a flexible infusion time

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Safety

Safety profile consistent with other cephalosporins

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Clinical & Scientific Data

​​​​ZINFORO® in the treatment of CAP and cSSTI​​​​​​

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These pages are not intended for patients or for members of the general public. The web pages contain promotional content. For the use only of Registered Medical Practitioners or a Hospital or a Laboratory. Full prescribing information available on request. For more details on, Who is a Registered Medical Practitioner, please visit "https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf", Page No. 39, Rule 2 part (ee), last accessed on 26th April2021.
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For more details on, Who is a Registered Medical Practitioner*, please visit https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf , Page No. 39, Rule 2 part (ee), last accessed on 13th September 2019.
​​​​​​​Address: The Capital, A Wing, 1802, 18th Floor, Plot No. C-70, 'G' Block, Bandra Kurla Complex, Bandra East, Mumbai - 400051.


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