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AboutUnmet NeedCommunity-acquired PneumoniaComplicated Skin & Soft Tissue InfectionsMode of ActionVideoCommunity-acquired PneumoniaComplicated Skin & Soft Tissue InfectionsPatient ProfilesProfiles of Patients With CAPIdentify ZINFORO® Patient With CAPProfiles of Patients With cSSTIIdentify ZINFORO® Patient With cSSTIDosingRecommended Dosing ScheduleSimple DosingRenal AdjustmentEfficacyCommunity-acquired PneumoniaClinical Efficacy: Proven Clinical EfficacyClinical Efficacy: Evidence of Rapid ResponsePivotal Clinical StudiesMicrobiology: Optimising OutcomesMicrobiology: CoverageMicrobiology: Low MIC ValuesComplicated Skin & Soft Tissue InfectionsClinical Efficacy: Proven Clinical EfficacyClinical Efficacy: Evidence of Rapid ResponsePivotal Clinical StudiesMicrobiology: Optimising OutcomesMicrobiology: CoverageMicrobiology: Low MIC ValuesSafetySafetyKey safety featuresLow Incidence of Discontinuation in CAPLow Incidence of Discontinuation in cSSTIClinical & Scientific Data Clinical & Scientific Data Efficacy in the Treatment of CAPClinical Cure Rates Against Relevant PathogensClinical Cure Rates Across Patient SubgroupsDemonstrated Superiority to CeftriaxoneEarly Clinical ResponseReal-world Efficacy in Elderly PatientsConsistent Clinical Cure Rates in cSSTIClinical Cure Rates in Common Causative PathogensClinical Cure Rates in Patients With ComorbiditiesEarly Clinical EfficacyReal-life Efficacy in Clinical PracticeSupport & ResourcesSupport & ResourcesClinical updatesPrescribing InformationVideosWebinars

Clinical Efficacy: Proven Clinical Efficacy

ZINFORO® has proven clinical efficacy across 6 Phase III, randomised, controlled, double-blind trials in adult patients with CAP and cSSTI.1-6

  

In the FOCUS 1 and FOCUS 2 studies, ZINFORO® was as effective as ceftriaxone in adult patients with CAP4:

  

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The efficacy of ZINFORO® (ceftaroline fosamil) was confirmed in patients with CAP in a real-world setting.


Clinical success in selected subgroups of the CAPTURE study7,8,*
 

 

High rates of overall clinical success were observed across various real-world patient subgroups.7,8,*​​​​​​​​​


*CAPTURE was a retrospective cohort study relating to the current treatment practice in the United States. In CAPTURE, ‘clinical success’ was defined as a clinical cure with no further need for antibiotic therapy or clinical improvement with a switch to oral agents at the end of ZINFORO® (ceftaroline fosamil) treatment. As CAPTURE is a retrospective chart review study, it has the limitations inherent to this study design.7,8

CAP, community-acquired pneumonia; CAPTURE, Clinical Assessment Program and Teflaro® Utilization Registry; CE, clinically evaluable; CI, confidence interval; cSSTI, complicated skin and soft tissue infection; MITTE, modified intent-to-treat efficacy; q12h, every 12 hours; q24h, every 24 hours.
​​​​​​​

References:

Corey GR, Wilcox M, Talbot GH, et al. Integrated analysis of CANVAS 1 and 2: phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infection. Clin Infect Dis. 2010;51(suppl 6):641-650.Friedland HD, O'Neal T, Biek D, et al. CANVAS 1 and 2: analysis of clinical response at day 3 in two phase 3 trials of ceftaroline fosamil versus vancomycin plus aztreonam in treatment of acute bacterial skin and skin structure infections. Antimicrob Agents Chemother. 2012;56(suppl 5):2231-2236.Dryden M, Zhang Y, Wilson D, Iaconis JP, Gonzalez J. A Phase III, randomized, controlled, non-inferiority trial of ceftaroline fosamil 600 mg every 8 h versus vancomycin plus aztreonam in patients with complicated skin and soft tissue infection with systemic inflammatory response or underlying comorbidities. J Antimicrob Chemother. 2016;71(suppl 12):3575-3584.File TM Jr, Low DE, Eckburg PB, et al. Integrated analysis of FOCUS 1 and FOCUS 2: randomized, doubled-blinded, multicenter phase 3 trials of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in patients with community-acquired pneumonia [published correction appears in Clin Infect Dis. 2011 Apr 1;52(7):967]. Clin Infect Dis. 2010;51(suppl 12):1395-1405.Eckburg PB, Friedland H, Llorens L. et al. Day 4 Clinical Response of Ceftaroline Fosamil Versus Ceftriaxone for Community-Acquired Bacterial Pneumonia. Infect Dis Clin Pract. 2012;20:254-260.Zhong NS, Sun T, Zhuo C, et al. Ceftaroline fosamil versus ceftriaxone for the treatment of Asian patients with community-acquired pneumonia: a randomised, controlled, double-blind, phase 3, non-inferiority with nested superiority trial. Lancet Infect Dis. 2015;15(suppl 2):161-171.Udeani G, Evans J, Cole P, Friedland HD. Ceftaroline fosamil for the treatment of community-acquired bacterial pneumonia in elderly patients. Hosp Pract (1995). 2014;42(suppl 3):109-115.Maggiore C, Pasquale T, Cole P, Friedland HD. Ceftaroline fosamil for treating skin and skin structure infections or community-acquired pneumonia in patients with renal insufficiency. Expert Rev Clin Pharmacol. 2015;8(suppl 1):141-153.


​​​​​Please click the Prescribing Information link to view the safety and adverse events information of ZINFORO®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.
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PP-ZFO-IND-0417 June 2022

Community-acquired Pneumonia


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Fifth-generation cephalosporin with broad coverage

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Dosing

Simple dosing with a flexible infusion time

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Safety

Safety profile consistent with other cephalosporins

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Clinical & Scientific Data

​​​​ZINFORO® in the treatment of CAP and cSSTI​​​​​​

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