ATTR is an underdiagnosed disease. Learn to suspect and detect the clinical clues.1
Amyloidosis refers to a group of diseases in which amyloid fibrils deposit into the extracellular spaces of multiple organs and nerves, ultimately leading to progressive organ dysfunction and nerve damage.1,2
ATTR amyloidosis is caused by the destabilisation and misfolding of the TTR protein, a tetrameric transporter of thyroxine and retinol-binding proteins.1,3
Because the symptoms are similar to those of other conditions and because it impacts multiple systems in the body, ATTR is often underdiagnosed.1
A multidisciplinary approach can help recognise the red flags of ATTR that are present throughout the body.4
There are 2 primary manifestations of ATTR amyloidosis: ATTR-CM and ATTR-PN.5,6
Patients with ATTR-CM present with symptoms of heart failure and may also present with other symptoms, such as atrial fibrillation, carpal tunnel syndrome or peripheral neuropathy.1,8-11
Any suspicion of cardiac involvement should prompt an immediate cardiac evaluation to rule out ATTR-CM.4
Multidisciplinary care that involves a partnership with cardiologists can uncover appropriate treatments that may lead to improved outcomes.4
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