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DosingRecommended dose modificationsDose Administration

Mechanism of Action

BeneFIX contains recombinant coagulation FIX, (nonacog alfa). Recombinant coagulation FIX is a single-chain glycoprotein with an approximate molecular mass of 55,000 Da that is a member of the serine protease family of vitamin K-dependent coagulation factors. 

Recombinant coagulation FIX is a recombinant DNA-based protein therapeutic which has structural and functional characteristics comparable to endogenous FIX. FIX is activated by factor VII/tissue factor complex in the extrinsic pathway as well as factor XIa in the intrinsic coagulation pathway. 

Activated FIX, in combination with activated factor VIII, activates factor X. This results ultimately in the conversion of prothrombin to thrombin. Thrombin then converts fibrinogen into fibrin and a clot can be formed. FIX activity is absent or greatly reduced in patients with hemophilia B and substitution therapy may be required.

  

Learn how BeneFIX® (nonacog alfa) can be used for the treatment and prophylaxis of bleeding in patients with hemophilia B

  

Coming soon...

  

  

Da, daltons; FIX, factor IX.

  

Reference:

BeneFIX. Local prescribing document. Pfizer India. LPDBEN092021.


PP-BEN-IND-0025 22/07/22

About


Dosing

BeneFIX® provides dosing options based on individual needs

Learn more


Efficacy and Safety

Proven efficacy and protection across dosing regimen

Review efficacy  profile


Real-world Data

See how BeneFIX® performs in real-life settings.

Review real-world data

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