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DosingRecommended dose modificationsDose Administration

Patient Actively Involved in Sport

Considerations for choosing an appropriate factor product


More frequent dosing may provide higher factor levels1


Depending on patients' needs and lifestyles, continuing with or switching to an SHL factor product may represent an appropriate option.1

Higher factor levels and more frequent peaks may be needed for some patients.1
  • The importance of peak and trough levels in hemophilia patients is still not clearly understood. However, studies suggest that higher trough levels and greater area under the curve may correlate to fewer bleeds, especially in joints.2
  • In patients with more sedentary lifestyles longer dose intervals may be acceptable.1
  • In patients with a less than average half-life prolongation, target joints,* or more on-the move lifestyles, higher and more frequent peak factor levels may be beneficial for sufficient bleed protection. 1,3
BeneFIX® offers the flexibility to infuse on-demand or prophylactically based on your patients' needs.4  Rohan – a patient actively involved in sport  Patient profiles are hypothetical and for discussion purposes only.  Who is Rohan?

Child actively involved in sports

A 12-year-old patient with moderate hemophilia B. He is voted “Most Likely to Succeed” by his classmates and enjoys riding his bike with his friends.




Rohan is currently on prophylaxis with BeneFIX® at a dose of 60 IU/kg every 4 to 5 days.

He has experienced 2 bleeding episodes in his knee in the past year and has a history of inhibitor formation. His parents are reluctant to change his treatment.


These higher-risk patients often participate in non-contact sports or athletic training, such as swimming, cycling, golfing, or rowing. Patients who plan to engage in certain physical activities may benefit from higher levels and more frequent peaks.1,9,11

Why BeneFIX® may be appropriate for patients like Rohan


Efficacy that is established
for prophylaxis, on-demand and surgery5,7,8
Convenient storage options
storage flexibility through room temperature storage (2 - 30 °C).4 Do not freeze4
Flexible dosing
with a predictable PK to support your patient's everyday life10
Favourable safety
with low inhibitor formation6
A broad range of vial sizes
(250, 500, 1000, 2000, 3000 IU) so you can individualise FIX coverage for your patients4


Informed decisions may lead to more favourable outcomes.1,3


To help ensure that patients are actively involved in creating their treatment plan, consider discussing the following points to help determine if an SHL or an EHL is more appropriate:

  • Lifestyle and activity level
  • Bleed pattern
  • Joint health
  • PK profile


*A target joint is a joint in which 3 or more spontaneous bleeds occurred within a consecutive  6-month period.9


EHL, extended half-life; FIX, factor IX; PK, pharmacokinetics; SHL, standard half-life.



Collins P, Chalmers E, Chowdary P, et al. The use of enhanced half-life coagulation factor concentrates in routine clinical practice: guidance from UKHCDO. Haemophilia. 2016;22(4):487-498Dunn A. The long and short of it: using the new factor products. Hematology Am Soc Hematol Educ Program. 2015;2015:26-32.Nossair F, Thornburg CD. The role of patient and healthcare professionals in the era of new hemophilia treatments in developed and developing countries. Ther Adv Hematol. 2018;9(8):239-249.Local product document, Nonacog alfa (recombinant coagulation factor IX), BeneFIX® : LPDBEN062022.Roth DA, Kessler CM, Pasi KJ, et al. Human recombinant factor IX: safety and efficacy studies in hemophilia B patients previously treated with plasma-derived factor IX concentrates. Blood. 2001;98(13):3600-36066. Rendo P, Smith L, Lee HY, Shafer F. Nonacog alfa: an analysis of safety data from six prospective clinical studies in different patient populations with haemophilia B treated with different therapeutic modalities. Blood Coagul Fibrinolysis. 2015;26(8):912-918.Shapiro AD, Di Paola J, Cohen A, et al. The safety and efficacy of recombinant human blood coagulation factor IX in previously untreated patients with severe or moderately severe hemophilia B. Blood. 2005;105(2):518-525.Ragni MV, Pasi KJ, White GC, et al. Use of recombinant factor IX in subjects with haemophilia B undergoing surgery. Haemophilia. 2002;8(2):91-97.Srivastava A, Santagostino E, Dougall A, et al. WFH guidelines for the management of hemophilia, 3rd edition. Haemophilia. 2020;26(suppl 6):1-158.Korth-Bradley JM, Rendo P, Smith L, Altisent C. Pharmacokinetics, Efficacy, and Safety of Nonacog Alfa in Previously Treated Patients with Moderately Severe to Severe Hemophilia B. Clin Ther. 2016;38(4):936-944.Seuser A, Boehm P, Kurme A, Schumpe G, Kurnik K. Orthopaedic issues in sports for persons with haemophilia. Haemophilia. 2007;13 (suppl 2):47-52.


PP-BEN-IND-0038 June 2023

Patient Profiles


BeneFIX® provides dosing options based on individual needs

Learn more


Efficacy and Safety

Proven efficacy and protection across dosing regimen

Review efficacy profile


Real-world Data

See how BeneFIX® performs in real-life settings.

Review real-world data

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