Real-world data provide information about the efficacy and safety of rFIX products in everyday clinical practice.
Patients With Hemophilia B Receiving SHL rFIX
Data derived from a health record-based survey of European and US haematologists (n=150 patients with hemophilia B, 114 of whom were taking SHL rFIX). Overall, 67% of the overall group were on prophylactic rFIX, the remainder received on-demand treatment. Information is not available on the proportion of patients receiving on-demand rFIX treatment. n/N: n, number of patients with no missed doses in the last 10 doses; N, patients with physician-reported dose data.
No head-to-head trials comparing the efficacy of EHL versus SHL factor replacement products have been reported. The available real-world data are of small sample size, particularly for the FIX EHL groups. Therefore, these data are subject to biases and other limitations (e.g. recall and selection biases, retrospective non-randomised cross-sectional study, small sample size (particularly for the EHL group) and lack of data adjustment for treatment regimens).
Patients With Hemophilia B Receiving EHL rFIX
Data derived from a health-record based survey of European and US haematologists (n=150 patients with hemophilia B, 36 of whom were taking EHL rFIX). Overall, 67% of the overall group were on prophylactic rFIX, the remainder received on-demand treatment. Information is not available on the proportion of patients receiving on-demand rFIX treatment. n/N: n, number of patients with no missed doses in the last 10 doses; N, patients with physician-reported dose data.
ABR, annualised bleed rate; EHL, extended half-life; FIX, factor IX; rFIX, recombinant factor IX; SHL, standard half-life.
PP-BEN-IND-0025 22/07/22
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