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AboutAboutMOA & IndicationsWhy Eliquis®?Dosage & SwitchDosage & SwitchSPAF DosingVTE DosingEfficacy & SafetyEfficacy & SafetyRCT Data: Efficacy and Safety in SPAFRCT Data: Efficacy and Safety in VTERCT Data: Efficacy and Safety in SPAFEliquis® in a Broad Range of Patients With NVAFApixaban & Other NOACsApixaban & Other NOACsApixaban & Other NOACsSupport & ServicesSupport & ServicesSummary of Prescribing InformationExpert Webinars

MOA & Indications

Mechanism of Action   

Pharmacotherapeutic group: Antithrombotic agents, direct factor Xa inhibitors, ATC code: B01AF025

   

Apixaban is a potent, oral, reversible, direct and highly selective active site inhibitor of factor Xa. It does not require antithrombin III for antithrombotic activity. Apixaban inhibits free and clot-bound factor Xa, and prothrombinase activity. Apixaban has no direct effects on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin. By inhibiting factor Xa, apixaban prevents thrombin generation and thrombus development. Preclinical studies of apixaban in animal models have demonstrated antithrombotic efficacy in the prevention of arterial and venous thrombosis at doses that preserved haemostasis.5

Therapeutic Indications   

Prevention of stroke and SE in adult patients with NVAF, including those with one or more risk factors, such as prior stroke or TIA, age ≥75 years, hypertension, diabetes mellitus and symptomatic heart failure (NYHA Class ≥II). Compared with warfarin, apixaban also results in less bleeding, including intracranial haemorrhage.5

Prevention of VTE in adult patients who have undergone elective hip or knee replacement surgery.5

Treatment of DVT and PE, and prevention of recurrent DVT and PE in adult patients.5

   

  

DVT, deep vein thrombosis; NVAF, non-valvular atrial fibrillation; NYHA, New York Heart Association; PE, pulmonary embolism; SE, systemic embolism; TIA, transient ischaemic attack; VTE, venous thromboembolic event; Xa, xaban.

  

References:

Granger CB, Alexander JH, McMurray JJ, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365(11):981-992.Ruff CT, Giugliano RP, Braunwald E, et al. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet. 2014;383(9921):955-962.Hur M, Park SK, Koo CH, et al. Comparative efficacy and safety of anticoagulants for prevention of venous thromboembolism after hip and knee arthroplasty. Acta Orthop. 2017;88(6):634-641.Cohen AT, Imfeld S, Rider T. Phase III trials of new oral anticoagulants in the acute treatment and secondary prevention of VTE: comparison and critique of study methodology and results. Adv Ther. 2014;31(5):473-493.Eliquis. Local product document. Pfizer; 2022. LPDELI062022. Version 16.   

Disclaimer: The products discussed herein may have different product labelling in different countries. The product information provided in this site is intended only for the residents of India.

   

Please click the Prescribing Information link to view the safety and adverse events information of Eliquis®.
For the use only of Registered Medical Practitioners, or a hospital or a laboratory.

  

PP-ELI-IND-1567 25 July 2022

   

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