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AboutIntroducing Enbrel®Heritage of Enbrel®IndicationsTherapeutic IndicationsRheumatoid ArthritisJuvenile Idiopathic ArthritisPsoriatic ArthritisAxial SpondyloarthritisPsoriasis & Paediatric PsoriasisMechanism of actionMode of ActionHalf-lifeDosingDosingRheumatoid Arthritis, Psoriatic Arthritis & Axial SpondyloarthritisJuvenile Idiopathic ArthritisPsoriasisPaediatric PsoriasisAdministration & StorageAdministrationMYCLIC®StorageEfficacy & SafetyEfficacyRapid EffectivenessSustained EffectivenessEffectiveness With Monotherapy or Combination TherapySafetyTolerability Across IndicationsSummary of Prescribing InformationImmunogenicityImmunogenicity & Clinical ResponseImmunogenicity & Enbrel®Experience & InsightsExperience & InsightManufacturingPatient StoriesRheumatoid ArthritisPatient With an Increased Risk of Serious InfectionsMTX-IR PatientPatient Who Is Considering Starting a FamilyElderly-onset RA PatientYoung Patient Worried About the Lifelong Impact of RAYoung Patient Worried About Treatments That Lose Effectiveness Over TimeJuvenile Idiopathic ArthritisJuvenile PatientPatient Moving From Childhood to AdolescenceAxial SpondyloarthritisAS Patients With Heel EnthesitisAS Patients With Functional LimitationsAdvanced AS PatientsPsoriatic Arthritis & PsoriasisPsO Patient With Severe SymptomsPsO Patients With Cyclical SymptomsPsA Patient With Metabolic SyndromePsA Patient With Multiple Skin & Joint SymptomsSupport & ServicesSupport & ServicesUsing Enbrel®Summary of Prescribing InformationPatient ResourcesEventsMaterialsVideos

Heritage of Enbrel®

Enbrel® is celebrating 21 years of timeless trust1

  • Experience of over 6 million patient-years1
     
  • Clinically proven, backed up with more than 500 clinical trials2
  • Approved in 100+ countries3

Enbrel® is supported by a wealth of evidence4-7
  • Real-world data from 7 clinical registries and 8 OLE studies have shown long-term disease control and sustained drug survival with Enbrel®8-16
     
  • Accredited with more than 7000 published articles17

      

OLE, open-label extension.

      

References:

PERIODIC SAFETY UPDATE REPORT 26 for ACTIVE SUBSTANCE: ETANERCEPT. Etanercept Reporting Period Periodic Safety Update Report (PSUR) 26. Pfizer. 2019; 1-951.Etanercept. Search results. NIH, U.S. National Library of Medicine. Accessed on July 19, 2022. https://clinicaltrials.gov/ct2/results?cond=&term=etanercept&cntry=&state=&city=&dist=Data on file. Approvals. Pfizer. 2018.
A study to evaluate the efficacy of Enbrel (REGISTERED) Etanercept over a period of 12 months in the routine treatment of patients with rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis, or plaque psoriasis. U.S. National Library of Medicine. Accessed May 5, 2022. https://clinicaltrials.gov/ct2/show/results/NCT02486302
Etanercept publications. U.S. National Library of Medicine. Accessed May 5, 2022.
https://pubmed.ncbi.nlm.nih.gov/?term=etanercept+publicationsPrinz JC, Puig L, Girolomoni G. Treatment of psoriasis with etanercept: the typical patient profile. J Eur Acad Dermatol Venereol. 2016;30(7):1092-1099.Enbrel. Local product document. Version LPDENB062021.Scott LJ. Etanercept: a review of its use in autoimmune inflammatory diseases. Drugs. 2014;74(12):1379-1410.Favalli EG, Pregnolato F, Biggioggero M, et al. Twelve-year retention rate of first-line tumor necrosis factor inhibitors in rheumatoid arthritis: real-life data from a local registry. Arthritis Care Res (Hoboken). 2016;68(4):432-439.Neovius M, Arkema EV, Olsson H, et al. Drug survival on TNF inhibitors in patients with rheumatoid arthritis comparison of adalimumab, etanercept and infliximab. Ann Rheum Dis. 2015;74(2):354-360.Hetland ML, Christensen IJ, Tarp U, et al. Direct comparison of treatment responses, remission rates, and drug adherence in patients with rheumatoid arthritis treated with adalimumab, etanercept, or infliximab: results from eight years of surveillance of clinical practice in the nationwide Danish DANBIO registry. Arthritis Rheum. 2010;62(1):22-32.Kievit W, Adang EM, Fransen J, et al. The effectiveness and medication costs of three anti-tumour necrosis factor alpha agents in the treatment of rheumatoid arthritis from prospective clinical practice data. Ann Rheum Dis. 2008;67(9):1229-1234.Strangfeld A, Hierse F, Kekow J, et al. Comparative effectiveness of tumour necrosis factor alpha inhibitors in combination with either methotrexate or leflunomide. Ann Rheum Dis. 2009;68(12):1856-1862.Marchesoni A, Zaccara E, Gorla R, et al. TNF-alpha antagonist survival rate in a cohort of rheumatoid arthritis patients observed under conditions of standard clinical practice. Ann N Y Acad Sci. 2009;1173:837-846.Iannone F, Gremese E, Atzeni F, et al. Long-term retention of tumor necrosis factor-α inhibitor therapy in a large Italian cohort of patients with rheumatoid arthritis from the GISEA registry: an appraisal of predictors. J Rheumatol. 2012;39(6):1179-1184.Weinblatt ME, Bathon JM, Kremer JM, et al. Safety and efficacy of etanercept beyond 10 years of therapy in North American patients with early and longstanding rheumatoid arthritis. Arthritis Care Res (Hoboken). 2011;63(3):373-382.Etanercept. Search Results. NIH, National Library of Medicine. National Center for Biotechnology Information. PubMed. Accessed on July 19, 2022. https://pubmed.ncbi.nlm.nih.gov/?term=etanercept

      

Please click the Prescribing Information link to view the safety and adverse events information of Enbrel®.
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Introducing Enbrel®
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