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AboutIntroducing Enbrel®Heritage of Enbrel®IndicationsTherapeutic IndicationsRheumatoid ArthritisJuvenile Idiopathic ArthritisPsoriatic ArthritisAxial SpondyloarthritisPsoriasis & Paediatric PsoriasisMechanism of actionMode of ActionHalf-lifeDosingDosingRheumatoid Arthritis, Psoriatic Arthritis & Axial SpondyloarthritisJuvenile Idiopathic ArthritisPsoriasisPaediatric PsoriasisAdministration & StorageAdministrationMYCLIC®StorageEfficacy & SafetyEfficacyRapid EffectivenessSustained EffectivenessEffectiveness With Monotherapy or Combination TherapySafetyTolerability Across IndicationsSummary of Prescribing InformationImmunogenicityImmunogenicity & Clinical ResponseImmunogenicity & Enbrel®Experience & InsightsExperience & InsightManufacturingPatient StoriesRheumatoid ArthritisPatient With an Increased Risk of Serious InfectionsMTX-IR PatientPatient Who Is Considering Starting a FamilyElderly-onset RA PatientYoung Patient Worried About the Lifelong Impact of RAYoung Patient Worried About Treatments That Lose Effectiveness Over TimeJuvenile Idiopathic ArthritisJuvenile PatientPatient Moving From Childhood to AdolescenceAxial SpondyloarthritisAS Patients With Heel EnthesitisAS Patients With Functional LimitationsAdvanced AS PatientsPsoriatic Arthritis & PsoriasisPsO Patient With Severe SymptomsPsO Patients With Cyclical SymptomsPsA Patient With Metabolic SyndromePsA Patient With Multiple Skin & Joint SymptomsSupport & ServicesSupport & ServicesUsing Enbrel®Summary of Prescribing InformationPatient ResourcesEventsMaterialsVideos

Mode of Action 

Enbrel® is a soluble TNFR fusion protein1

  • Much of the disease pathology in RA, AS and PsO is mediated by proinflammatory molecules that are linked in a network controlled by TNF
     
  • The mechanism of action of Enbrel® involves the competitive inhibition of TNF binding to the cell surface TNFRs, which thereby inhibits the biological activity of TNF1
     
  • Enbrel® may also modulate biologic responses controlled by additional downstream molecules (e.g. cytokines, adhesion molecules or proteinases) that are induced or regulated by TNF1
  • Enbrel® has a specific structure (which binds with human tumour necrosis factor receptor) and mechanism of action2-4
     
  • Enbrel® mimics the activity of naturally occurring soluble TNFRs by acting as a competitive inhibitor of TNF7 and preventing TNF-mediated cellular responses2

Enbrel® is the only fully human soluble TNFR2

   

Enbrel® works like a naturally occurring soluble TNFR and inhibits TNF.2

   

   

   

   

   

*Mean half-life of approximately 4.3 days (70–100 hours)

   

PASI 75 improvements were seen as early as 2 weeks with etanercept 25 mg BIW and 50 mg BIW5.

Disclaimer: The approved dose for Psoriasis is etanercept 25 mg BIW or 50 mg OW and 50 mg BIW can be used upto 12 weeks followed by 25 mg BIW/ 50 mg OW.

   

AS, ankylosing spondylitis; Fc, fragment crystallisable; IgG1, immunoglobulin G1; PASI, Psoriasis Area and Severity Index; PsA, psoriatic arthritis; PsO, psoriasis; QoL, quality of life; RA, rheumatoid arthritis; TNF, tumour necrosis factor; TNF-α, tumour necrosis factor alpha; TNFR, tumour necrosis factor receptor.

   

References:

Enbrel. Local product document. Version LPDENB062021.Enbrel (etanercept) Summary of Product Characteristics.Accessed July 18, 2022. https://www.ema.europa.eu/en/documents/product-information/enbrel-epar-product-information_en.pdfNguyen TU, Koo J. Etanercept in the treatment of plaque psoriasis. Clin Cosmet Investig Dermatol. 2009;2:77-84.Mpofu S, Fatima F, Moots RJ. Anti-TNF-alpha therapies: they are all the same (aren't they?). Rheumatology (Oxford). 2005;44(3):271-273.Leonardi CL, Powers JL, Matheson RT, et al. Etanercept as monotherapy in patients with psoriasis. N Engl J Med. 2003;349(21):2014-2022.Papp KA, Poulin Y, Bissonnette R, et al. Assessment of the long-term safety and effectiveness of etanercept for the treatment of psoriasis in an adult population. J Am Acad Dermatol. 2012;66(2):e33-e45.Strohal R, Puig L, Chouela E, et al. The efficacy and safety of etanercept when used with as-needed adjunctive topical therapy in a randomised, double-blind study in subjects with moderate-to-severe psoriasis (the PRISTINE trial). J Dermatolog Treat. 2013;24(3):169-178.Balsa A, Lula S, Marshall L, Szczypa P, Aikman L. The comparative immunogenicity of biologic therapy and its clinical relevance in psoriatic arthritis: a systematic review of the literature. Expert Opin Biol Ther. 2018;18(5):575-584.

   

Please click the Prescribing Information link to view the safety and adverse events information of Enbrel®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

    

PP-ENB-IND-0814 August 2022

    

Mechanism of Action
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