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LORBRIQUA® (lorlatinib) is indicated for the treatment of adult patients with ALK+ metastatic NSCLC.1

Study Methodology

CROWN trial2
 

LORBRIQUA® is a third-generation ALK inhibitor that was evaluated in a global, open-label, randomised, multicentre, Phase 3 trial2

Brand A-Z

Adapted from Shaw AT, et al. 2020.

    

Primary endpoint

  • PFS by BICR

Secondary endpoints:

  • PFS by investigator
  • ORR by BICR and investigator
  • IC-ORR, DoR and IC-DoR by BICR
  • IC time to progression by BICR
  • OS
  • Safety
  • QoL

Baseline Characteristics2

  

  

Adapted from Shaw AT, et al. 2020.

  

  

*Based on the BICR assessment.

   

ALK, anaplastic lymphoma kinase; ALK+, anaplastic lymphoma kinase-positive; BICR, blinded independent central review; BID, twice a day; CNS, central nervous system; DoR, duration of response; ECOG PS, Eastern Cooperative Oncology Group performance status; IC, intracranial; IC-DoR, intracranial duration of response; IC-ORR, intracranial overall response rate; IQR, interquartile range; NSCLC, non-small cell lung cancer; ORR, objective response rate; OS, overall survival; PFS, progression-free survival; QD, once a day; QoL, quality of life; RECIST v1.1, Response Evaluation Criteria in Solid Tumours version 1.1.

   

References:

Lorbriqua. Local product document. Pfizer; 2021. Version LPDLOR082021.Shaw AT, Bauer TM, de Marinis F, et al. CROWN Trial Investigators. First-line lorlatinib or crizotinib in advanced ALK-positive lung cancer. N Engl J Med. 2020;383(21):2018-2029.

   

Please click the Prescribing Information link to view the safety and adverse events information of LORBRIQUA®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.​​​​​​

   

PP-LOR-IND-0129 June 2022

About Brand A-Z

CNS Efficacy

82% IC response rate with LORBRIQUA® in patients with measurable brain metastases at baseline (BICR assessed)

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Brand A-Z

Efficacy & Safety


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These pages are not intended for patients or for members of the general public. The web pages contain promotional content. For the use only of Registered Medical Practitioners or a Hospital or a Laboratory. Full prescribing information available on request. For more details on, Who is a Registered Medical Practitioner, please visit "https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf", Page No. 39, Rule 2 part (ee), last accessed on 26th April2021.
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PP-LOR-IND-0129

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​​​​​​​Address: The Capital, A Wing, 1802, 18th Floor, Plot No. C-70, 'G' Block, Bandra Kurla Complex, Bandra East, Mumbai - 400051.


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