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LORBRIQUA® (lorlatinib) is indicated for the treatment of adult patients with ALK+ metastatic NSCLC.1

CNS Efficacy

IC-ORR by BICR2

  

Lorlatinib demonstrated 82% IC-ORR in patients with measurable brain metastases at baseline

   Adapted from Shaw AT, et al. 2020.    82% IC Response Rate With LORBRIQUA® in 17 Patients With Measurable Brain Metastases at Baseline (BICR Assessed)2,†

  

Example

   

IC Time to Progression by BICR2,3

   

  

Adapted from Shaw AT, et al. 2020.

   


*OR >1 indicates better outcome for lorlatinib relative to crizotinib.
†LORBRIQUA®, n=17; crizotinib, n=13 with measurable CNS lesions at baseline as assessed by the BICR.

    

ALK+, anaplastic lymphoma kinase-positive; BICR, blinded independent central review; CI, confidence interval; CNS, central nervous system; CR, complete response; DoR, duration of response; ESMO, European Society for Medical Oncology; HR, hazard ratio; IC, intracranial; IC-ORR, intracranial objective response rate; NE, not evaluable; NR, not reached; NSCLC, non-small cell lung cancer; OR, odds ratio; PR, partial response.


References:

Lorbriqua. Local product document. Pfizer; 2021. Version LPDLOR082021.Shaw AT, Bauer TM, de Marinis F, et al. CROWN Trial Investigators. First-line lorlatinib or crizotinib in advanced ALK-positive lung cancer. N Engl J Med. 2020;383(21):2018-2029.Solomon B, Bauer TM, De Marinis F, et al. LBA2 - Lorlatinib vs crizotinib in the first-line treatment of patients (pts) with advanced ALK-positive non-small cell lung cancer (NSCLC): results of the phase 3 CROWN study. Paper presented at: European Society for Medical Oncology (ESMO) Virtual Congress; September 19-21, 2020. Accessed March 15, 2016. https://oncologypro.esmo.org/meeting-resources/esmo-virtual-congress-2020/lorlatinib-vs-crizotinib-in-the-first-line-treatment-of-patients-pts-with-advanced-alk-positive-non-small-cell-lung-cancer-nsclc-results-of-th

   

Please click the Prescribing Information link to view the safety and adverse events information of LORBRIQUA®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.​​​​​​

   

PP-LOR-IND-0129 June 2022

Efficacy & Safety

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These pages are not intended for patients or for members of the general public. The web pages contain promotional content. For the use only of Registered Medical Practitioners or a Hospital or a Laboratory. Full prescribing information available on request. For more details on, Who is a Registered Medical Practitioner, please visit "https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf", Page No. 39, Rule 2 part (ee), last accessed on 26th April2021.
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