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LORBRIQUA® (lorlatinib) is indicated for the treatment of adult patients with ALK+ metastatic NSCLC.1

Summary

  • Lorlatinib resulted in a significantly longer PFS, significantly higher overall and IC response rates, and improved global QoL compared to crizotinib in first-line, treatment-naïve ALK+ NSCLC 1-2
     
    • Lorlatinib IC response rate was 82% in patients with measurable brain metastases, with a complete response rate of 71% and significantly longer time to IC progression
        
    • HR of 0.02 (95% CI 0.002- 0.14) for time to IC progression in patients without brain metastases suggests a CNS protective effect
       
  • The safety profile of lorlatinib was similar to that reported in previous studies.1-4
     
    • Grade 3/4 AEs were more frequent with lorlatinib than crizotinib, however the majority were laboratory abnormalities that were asymptomatic and readily managed
        
  • These results support the use of lorlatinib as an effective first-line therapy for patients with advanced ALK+ NSCLC 1-3

    

AEs, adverse events; ALK, anaplastic lymphoma kinase; ALK+, anaplastic lymphoma kinase-positive; CNS, central nervous system; HR, hazard ratio; IC, intracranial; NSCLC, non-small cell lung cancer; PFS, progression-free survival; QoL, quality of life.​​​​​

    

Reference:

Shaw AT, Solomon BJ, Chiari R, et al. Lorlatinib in advanced ROS1-positive non-small-cell lung cancer: a multicentre, open-label, single-arm, phase 1-2 trial. Lancet Oncol. 2019 Dec;20(12):1691-1701.Solomon BJ, BauerT, Mok T, et al. Updated Efficacy and Safety From the Phase 3 CROWN Study of First-Line Lorlatinib vs Crizotinib in Advanced Anaplastic Lymphoma Kinase (ALK)–Positive Non-Small Cell Lung Cancer (NSCLC). Poster CT223 presented at the AACR Annual Meeting 2022, April 8-13, 2022; New Orleans, Louisiana, USA.Solomon BJ, Besse B, Bauer TM, et al. Lorlatinib in patients with ALK-positive non-small-cell lung cancer: results from a global phase 2 study. Lancet Oncol. 2018 Dec;19(12):1654-1667.Bauer TM, Felip E, Solomon BJ, Thurm H, Peltz G, et al. Clinical Management of Adverse Events Associated with Lorlatinib. Oncologist. 2019 Aug;24(8):1103-1110.

    

Please click the Prescribing Information link to view the safety and adverse events information of LORBRIQUA®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.​​​​​​

    

PP-LOR-IND-0129 June 2022

    

    

Summary


American Cancer Society

The American Cancer Society funds and conducts research, shares expert information and provides support for patients who have been affected by cancer.

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Lung Cancer Foundation of America

The Lung Cancer Foundation of America aims to improve the survivorship of patients with lung cancer through the funding of transformative science.

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These pages are not intended for patients or for members of the general public. The web pages contain promotional content. For the use only of Registered Medical Practitioners or a Hospital or a Laboratory. Full prescribing information available on request. For more details on, Who is a Registered Medical Practitioner, please visit "https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf", Page No. 39, Rule 2 part (ee), last accessed on 26th April2021.
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Address: The Capital,  A Wing, 1802, 18th Floor, Plot No. C-70, ‘G’ Block, Bandra Kurla Complex, Bandra East, Mumbai – 400051, India.
 
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For more details on, Who is a Registered medical practitioner*, please visit https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf , Page No. 39, Rule 2 part (ee), last accessed on 26th April 2021.
Address: The Capital, A Wing, 1802, 18th Floor, Plot No. C-70, 'G' Block, Bandra Kurla Complex, Bandra East, Mumbai - 400051.


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