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Burden of Disease
Burden of Disease
Risk Factors
Secondary Infections
Mechanism of Action
Prevention of Pneumococcal Disease
Need for Pneumococcal Vaccination
Cost-effectiveness of PCV13
Legacy of Prevenar
Safety
Conclusion
Dosing
Prevenar 13® Clinical Experience
Efficacy of Prevenar 13®
Effectiveness of Prevenar 13®
Indian Clinical Trials
Recommendations for Use
PCV13 in Pulmonology
PCV13 in Nephrology
PCV13 in Oncology
PCV13 in Rheumatology
PCV13 in Diabetes
PCV13 in HIV Infection
PCV13 in Cardiology
Resources
The burden of pneumococcal disease associated with S. pneumoniae can be effectively reduced through vaccination with PCVs. Evidence from clinical trials has revealed that PPSV23 is effective against IPD (with inconsistent effects in pneumococcal pneumonia) in the adult population, including the elderly group. PCV13 offers protection from IPD and also from non-invasive infections like pneumonia and acute otitis media. The PCVs are also reported to reduce the vaccine-type nasopharyngeal colonisation, thereby inducing herd immunity effect. This group of vaccines also lowers the incidence of antibiotic-resistant pneumococcal disease.1
In spite of the need for lowering pneumococcal disease burden, the fact that PCVs are among the most expensive vaccines hinders their introduction in several regions, and threatens their sustainability for use in some other settings. Therefore, evaluating the cost-effectiveness of PCV13, long-term budget implications and the potential benefits is crucial for sustaining its use in countries that have already introduced it, and to analyse its introduction in other countries.2
IPD, invasive pneumococcal disease; NIP, national immunisation programme; PCV, pneumococcal vaccine; PCV13, 13-valent pneumococcal conjugate vaccine; PPSV23, 23-valent pneumococcal plain polysaccharide vaccine.
References:
Please click the Prescribing Information link to view the safety and adverse events information of Prevenar 13®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.
PP-PRV-IND-0661 July 2023
Help protect your adult patients against pneumococcal pneumonia with single-dose administration
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Efficacy proven by the CAPiTA study
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The ACIP recommends routine use of PCV13 among adults
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