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Burden of Disease

Burden of Disease

Description of the DiseaseGlobal EpidemiologyIndian EpidemiologyPneumococcal Disease and InfluenzaChallenges

Risk Factors
 

Risk Factors

Secondary Infections
​​​​​​​

Secondary Infections

Mechanism of Action
​​​​​​​

Mechanism of Action

Prevention of Pneumococcal Disease
 

Polysaccharide VaccineConjugate VaccineDifference

Need for Pneumococcal Vaccination

In ElderlyIn India

Cost-effectiveness of PCV13
 

NeedIndian StudiesGlobal Studies

Legacy of Prevenar
 

ManufacturingCRM197Activation and ConjugationPneumococcal Disease and InfluenzaDistributionVideos

Safety
 

Safety

Conclusion
 

Conclusion
Dosing

Dosing
 

Adults ≥18 Years of AgeAdults ≥50 Years of AgeCOVID VaccinationFlu Vaccination
Efficacy

Prevenar 13® Clinical Experience
 

IntroductionClinical Trials

Efficacy of Prevenar 13®
 

IntroductionStudyObjectiveMethodologyCriteriaResultsConclusion

Effectiveness of Prevenar 13® 
 

IntroductionObjectiveMethodologyAnalysisResultsLimitationsLearningsConclusion

Indian Clinical Trials
 

IntroductionStudy DesignResultsLimitationsConclusion
Recommendations for Use

Recommendations for Use
 

ACIP 2019NCCN 2020RSSDI 2020IMA GuidelinesIAOH Guidelines for Working AdultsClinical Practice Guidelines 2019 (ICS/NCCP)The Geriatric Society of India, 2015Indian Society of Nephrology
FAQs

PCV13 in Pulmonology
 

RoleComplicationsClinical DataRecommendations

PCV13 in Nephrology
 

RoleClinical DataRecommendations

PCV13 in Oncology
 

RoleClinical DataRecommendations

PCV13 in Rheumatology
 

RoleComplicationsDataRecommendationsConsensus

PCV13 in Diabetes
 

RoleComplicationsDataRecommendations

PCV13 in HIV Infection
 

RoleBurdenPulmonary InfectionDataEfficacyRecommendations

PCV13 in Cardiology
 

RoleBurdenComplicationsDataRecommendations
Resources

Resources

Summary of Prescribing InformationDownloadable ResourcesEvents and WebinarsLatest Articles

Manufacturing

PCVs, in countries where implemented, have been successful in reducing the number of cases of vaccine-type diseases.1

Prevenar 13® represents a public health success for society worldwide.1

At Pfizer, we are proud of this achievement and recognise that it could not have happened without a highly experienced team, some of whom have been here for over 20 years,2 working closely with healthcare professionals around the world.

Pfizer strives for vaccine supply reliability3 by using a highly integrated and adaptable global manufacturing and distribution network.2-4

Thousands of dedicated manufacturing colleagues each play their role in bringing every single dose of Prevenar 13® to market and seek to maintain the highest quality standards.

To explain the manufacturing process of Prevenar 13®, we start with the production of the polysaccharides. These are repeated unit of sugars bonded together, present on the surface of the bacterial capsule.

There are 3 main processes: Fermentation, clarification and purification.

   

   

First, during the fermentation process, 13 different types of the bacteria S. pneumoniae are grown in production fermenters.

Each of these is a specific strain of the bacteria that expresses a unique polycapsular polysaccharide which has been assigned an individual identification number, referred to as a serotype.

Through clarification and then purification stages, the 13 different polysaccharides essential for Prevenar 13® are produced.

Quality and safety are built into every step of the polysaccharide manufacturing process and includes a variety of tests and checks throughout the process to help ensure consistency in every batch.

The 13 polysaccharides are then stored and are ready for the next stage.

Meanwhile, the carrier protein called CRM197 is manufactured. Bacterial cells in vials are grown under controlled conditions in increasing volumes of growth media until the final fermentation step, when the protein is produced by the bacteria. It is then processed through ultra-filtration and column chromatography.

Finally the CRM197 is bottled and stored in a frozen state. Automation is utilised throughout the process to ensure each batch is processed the same, assuring high quality standards.

   

   

   

CRM197, cross-reactive-material 197; PCV, pneumococcal conjugate vaccine.

   

References:

Prevenar 13. Local product document. Pfizer. Version LPDPRV052021.Data on file. Pfizer.2015 Annual review – manufacturing and supply chain. Pfizer. Accessed May 17, 2022. https://www.pfizer.com/sites/default/files/investors/financial_reports/annual_reports/2015/assets/pdfs/pfi2015ar-entire-site.pdfPfizer commitment Gavi Alliance. Pfizer. Accessed May 17, 2022. https://www.pfizer.com/about/responsibility/global-impact/the-gavi-alliance

   

Please click the Prescribing Information link to view the safety and adverse events information of Prevenar 13®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

   

PP-PRV-IND-0268 July 2022

Legacy of Prevenar

    

Dosing

Help protect your adult patients against pneumococcal pneumonia with single-dose administration

Learn more

   

Efficacy

Efficacy proven by the CAPiTA study

Learn more

   

Recommendations for Use

The ACIP recommends routine use of PCV13 among adults

Learn more

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These pages are not intended for patients or for members of the general public. The web pages contain promotional content. For the use only of Registered Medical Practitioners or a Hospital or a Laboratory. Full prescribing information available on request. For more details on, Who is a Registered Medical Practitioner, please visit "https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf", Page No. 39, Rule 2 part (ee), last accessed on 26th April2021.
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For more details on, Who is a Registered Medical Practitioner*, please visit https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf , Page No. 39, Rule 2 part (ee), last accessed on 13th September 2019.
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