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Burden of Disease

Burden of Disease

Description of the DiseaseGlobal EpidemiologyIndian EpidemiologyPneumococcal Disease and InfluenzaChallenges

Risk Factors
 

Risk Factors

Secondary Infections
​​​​​​​

Secondary Infections

Mechanism of Action
​​​​​​​

Mechanism of Action

Prevention of Pneumococcal Disease
 

Polysaccharide VaccineConjugate VaccineDifference

Need for Pneumococcal Vaccination

In ElderlyIn India

Cost-effectiveness of PCV13
 

NeedIndian StudiesGlobal Studies

Legacy of Prevenar
 

ManufacturingCRM197Activation and ConjugationPneumococcal Disease and InfluenzaDistributionVideos

Safety
 

Safety

Conclusion
 

Conclusion
Dosing

Dosing
 

Adults ≥18 Years of AgeAdults ≥50 Years of AgeCOVID VaccinationFlu Vaccination
Efficacy

Prevenar 13® Clinical Experience
 

IntroductionClinical Trials

Efficacy of Prevenar 13®
 

IntroductionStudyObjectiveMethodologyCriteriaResultsConclusion

Effectiveness of Prevenar 13® 
 

IntroductionObjectiveMethodologyAnalysisResultsLimitationsLearningsConclusion

Indian Clinical Trials
 

IntroductionStudy DesignResultsLimitationsConclusion
Recommendations for Use

Recommendations for Use
 

ACIP 2019NCCN 2020RSSDI 2020IMA GuidelinesIAOH Guidelines for Working AdultsClinical Practice Guidelines 2019 (ICS/NCCP)The Geriatric Society of India, 2015Indian Society of Nephrology
FAQs

PCV13 in Pulmonology
 

RoleComplicationsClinical DataRecommendations

PCV13 in Nephrology
 

RoleClinical DataRecommendations

PCV13 in Oncology
 

RoleClinical DataRecommendations

PCV13 in Rheumatology
 

RoleComplicationsDataRecommendationsConsensus

PCV13 in Diabetes
 

RoleComplicationsDataRecommendations

PCV13 in HIV Infection
 

RoleBurdenPulmonary InfectionDataEfficacyRecommendations

PCV13 in Cardiology
 

RoleBurdenComplicationsDataRecommendations
Resources

Resources

Summary of Prescribing InformationDownloadable ResourcesEvents and WebinarsLatest Articles

Flu Vaccination

Pneumococcal Disease Complicating Influenza1

   

Influenza predisposes individuals to developing bacterial CAP. During each of the influenza pandemics of the 20th century, secondary bacterial pneumonia was a frequent cause of illness and death, and S. pneumoniae (pneumococcus) was reported as the most common aetiology. These findings also apply to seasonal influenza.

   

S. pneumoniae remains a leading cause of vaccine-preventable illness and death in the United States. Recently, pneumococcal infections have been identified as an important complication in severe and fatal cases of 2009 H1N1 influenza virus infection. Importantly, however, approximately 70 million persons with existing PPSV indications (Table) are unvaccinated (National Health Interview Survey, 2007).

   

   

Use of PPSV During the 2009 H1N1 Influenza Pandemic1

   

CDC’s ACIP recommends a single dose of PPSV for all people ≥65 years of age and for persons 2 through 64 years of age with certain high-risk conditions. Most people in these groups are at increased risk of pneumococcal disease as well as serious complications from influenza virus infections. Single revaccination at least 5 years after the initial vaccination is recommended for people ≥65 years who were first vaccinated before the age of 65 years. Single revaccination is also recommended for people at the highest risk of disease, such as those who have functional and anatomical asplenia, and those who have an HIV infection, AIDS or malignancy and have at least 5 years elapsed from receipt of first vaccination. All people who have existing indications for PPSV should continue to be vaccinated according to the current ACIP recommendations during the 2009 H1N1 influenza pandemic. Special emphasis should be placed on vaccinating people 2 through 64 years of age who have established high-risk conditions for pneumococcal disease; PPSV coverage among this group is low, and this group may be more likely to develop secondary bacterial pneumonia after an influenza infection. Use of PPSV among people without current indications for vaccination is not recommended at this time.

   

Simultaneous Administration of Pneumococcal (PPSV) and Influenza Vaccines

   

Pneumococcal vaccine can be given at any time during the year and may be given at the same time as the influenza vaccine. Visits for seasonal and 2009 H1N1 influenza vaccination provide a convenient time to evaluate patients for the need for pneumococcal vaccination. Persons who cannot remember if they have ever had the pneumococcal vaccine should still be vaccinated.

   

US ACIP Recommendations for the Use of PPSV

   

   

   

ACIP, Advisory Committee on Immunization Practices; AIDS, acquired immunodeficiency syndrome; CAP, community-acquired pneumonia; CDC,Centers for Disease Control and Prevention; HIV, human immunodeficiency virus; PPSV, pneumococcal polysaccharide vaccine; PPSV23, 23-valent pneumococcal polysaccharide vaccine.

   

Reference:

Prevention of pneumococcal infections secondary to seasonal and 2009 H1N1 influenza viruses infection. Centers for Disease Control and Prevention. Accessed May 17, 2022. http://www.cdc.gov/h1n1flu/vaccination/provider/provider_pneumococcal.htm

   

Please click the Prescribing Information link to view the safety and adverse events information of Prevenar 13®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

   

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Dosing

Efficacy

Efficacy proven by the CAPiTA study

Learn more

   

Recommendations for Use

The ACIP recommends routine use of PCV13 among adults

Learn more

   

FAQs

FAQs related to different fields

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