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Burden of Disease

Burden of Disease

Description of the DiseaseGlobal EpidemiologyIndian EpidemiologyPneumococcal Disease and InfluenzaChallenges

Risk Factors
 

Risk Factors

Secondary Infections
​​​​​​​

Secondary Infections

Mechanism of Action
​​​​​​​

Mechanism of Action

Prevention of Pneumococcal Disease
 

Polysaccharide VaccineConjugate VaccineDifference

Need for Pneumococcal Vaccination

In ElderlyIn India

Cost-effectiveness of PCV13
 

NeedIndian StudiesGlobal Studies

Legacy of Prevenar
 

ManufacturingCRM197Activation and ConjugationPneumococcal Disease and InfluenzaDistributionVideos

Safety
 

Safety

Conclusion
 

ConclusionDosing

Dosing
 

Adults ≥18 Years of AgeAdults ≥50 Years of AgeCOVID VaccinationFlu VaccinationEfficacy

Prevenar 13® Clinical Experience
 

IntroductionClinical Trials

Efficacy of Prevenar 13®
 

IntroductionStudyObjectiveMethodologyCriteriaResultsConclusion

Effectiveness of Prevenar 13® 
 

IntroductionObjectiveMethodologyAnalysisResultsLimitationsLearningsConclusion

Indian Clinical Trials
 

IntroductionStudy DesignResultsLimitationsConclusionRecommendations for Use

Recommendations for Use
 

ACIP 2019NCCN 2020RSSDI 2020IMA GuidelinesIAOH Guidelines for Working AdultsClinical Practice Guidelines 2019 (ICS/NCCP)The Geriatric Society of India, 2015Indian Society of NephrologyFAQs

PCV13 in Pulmonology
 

RoleComplicationsClinical DataRecommendations

PCV13 in Nephrology
 

RoleClinical DataRecommendations

PCV13 in Oncology
 

RoleClinical DataRecommendations

PCV13 in Rheumatology
 

RoleComplicationsDataRecommendationsConsensus

PCV13 in Diabetes
 

RoleComplicationsDataRecommendations

PCV13 in HIV Infection
 

RoleBurdenPulmonary InfectionDataEfficacyRecommendations

PCV13 in Cardiology
 

RoleBurdenComplicationsDataRecommendationsResources

Resources

Summary of Prescribing InformationDownloadable ResourcesExplore EventsExplore VideosExplore MaterialsLatest Articles

Study Design

This open-label single-arm study was conducted at 12 sites across 6 states in India. The different states involved were Maharashtra (n=591), Karnataka (n=98), Uttar Pradesh (n=34), Gujarat (n=165), Tamil Nadu (n=25) and Andhra Pradesh (n=87).1 Eligible population included participants with pre-existing stable disease, that is, disease not requiring a significant change in hospitalisation or therapy, for worsening of the disease 12 weeks before receiving PCV13.1 Exclusion criteria included individuals with a documented S. pneumoniae infection in the past 5 years, immunocompromised or with immunodeficiency, previous pneumococcal vaccination within the last year or previously treated with immunosuppressive therapy. Informed consent was obtained from all participants in accordance with requirements of the Indian Ministry of Health and Welfare.1

   

Participants received a single dose of PCV13 (0.5 mL).1 The end points of the study included the measurement of functional antibody OPA titres induced by the 13 pneumococcal serotypes contained in PCV13 at 2 time points: one before and the other at 1 month after vaccination.

   

   

OPA, opsonic pneumococcal antibody; PCV13, 13-valent pneumococcal conjugate vaccine.

   

Reference:

Solanki BB, Juergens C, Chopada MB, et al. Safety and immunogenicity of a 13-valent pneumococcal conjugate vaccine in adults 50 to 65 years of age in India: an open-label trial. Hum Vaccin Immunother. 2017;13(9):2065-2071.

   

Please click the Prescribing Information link to view the safety and adverse events information of Prevenar 13®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

   

PP-PRV-IND-0661 July 2023

Indian Clinical Trials

Dosing

Help protect your adult patients against pneumococcal pneumonia with single-dose administration

Learn more

Dosing

Help protect your adult patients against pneumococcal pneumonia with single-dose administration

Learn more

Dosing

Help protect your adult patients against pneumococcal pneumonia with single-dose administration

Learn more

Recommendations for Use

The ACIP recommends routine use of PCV13 among adults

Learn more

FAQs

FAQs related to different fields

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