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Burden of Disease

Burden of Disease

Description of the DiseaseGlobal EpidemiologyIndian EpidemiologyPneumococcal Disease and InfluenzaChallenges

Risk Factors
 

Risk Factors

Secondary Infections
​​​​​​​

Secondary Infections

Mechanism of Action
​​​​​​​

Mechanism of Action

Prevention of Pneumococcal Disease
 

Polysaccharide VaccineConjugate VaccineDifference

Need for Pneumococcal Vaccination

In ElderlyIn India

Cost-effectiveness of PCV13
 

NeedIndian StudiesGlobal Studies

Legacy of Prevenar
 

ManufacturingCRM197Activation and ConjugationPneumococcal Disease and InfluenzaDistributionVideos

Safety
 

Safety

Conclusion
 

Conclusion
Dosing

Dosing
 

Adults ≥18 Years of AgeAdults ≥50 Years of AgeCOVID VaccinationFlu Vaccination
Efficacy

Prevenar 13® Clinical Experience
 

IntroductionClinical Trials

Efficacy of Prevenar 13®
 

IntroductionStudyObjectiveMethodologyCriteriaResultsConclusion

Effectiveness of Prevenar 13® 
 

IntroductionObjectiveMethodologyAnalysisResultsLimitationsLearningsConclusion

Indian Clinical Trials
 

IntroductionStudy DesignResultsLimitationsConclusion
Recommendations for Use

Recommendations for Use
 

ACIP 2019NCCN 2020RSSDI 2020IMA GuidelinesIAOH Guidelines for Working AdultsClinical Practice Guidelines 2019 (ICS/NCCP)The Geriatric Society of India, 2015Indian Society of Nephrology
FAQs

PCV13 in Pulmonology
 

RoleComplicationsClinical DataRecommendations

PCV13 in Nephrology
 

RoleClinical DataRecommendations

PCV13 in Oncology
 

RoleClinical DataRecommendations

PCV13 in Rheumatology
 

RoleComplicationsDataRecommendationsConsensus

PCV13 in Diabetes
 

RoleComplicationsDataRecommendations

PCV13 in HIV Infection
 

RoleBurdenPulmonary InfectionDataEfficacyRecommendations

PCV13 in Cardiology
 

RoleBurdenComplicationsDataRecommendations
Resources

Resources

Summary of Prescribing InformationDownloadable ResourcesEvents and WebinarsLatest Articles

Data

Clinical and Immunogenicity Data of Pneumococcal Vaccines in Patients With Diabetes

   

A study from the United States revealed that use of PCV13 in adults with diabetes, aged <65 years, could substantially reduce the incidence of pneumonia-related hospitalisations in these patients. Out of the 15 million adults aged <65 years, and with diabetes, in the US, there were 250,000 annual hospitalisations for CAP. The study revealed that PCV13 vaccination in this adult population with diabetes could avert 206,955 to 373,854 hospital days and 24,638 to 44,506 hospitalisations over a 5-year period. Moreover, to avert 1 hospital day and incidence of 1 hospitalization, the number of PCV13 vaccinations required in this population were 41 to 74 and 344 to 622, respectively. The study revealed that the number needed to vaccinate with PCV13 for averting 1 case of CAP in this population with diabetes was similar to the number shown in existing guidelines for elder patients. Therefore, the study concluded that use of PCV13 in adults aged <65 years might significantly reduce the number of pneumonia-related hospitalisations.1

   

A post hoc analysis of the CAPiTA trial reported that the effectiveness of PCV13 was significantly higher in patients with diabetes mellitus who were aged ≥65 years (P = 0.002). The vaccine effectiveness of PCV13 in elderly individuals with or without diabetes mellitus were 89.5% (95% CI, 65.5-96.8) and 24.7% (95% CI, −10.4 to 48.7), respectively.2

   

   

CAP, community-acquired pneumonia; CAPiTA, Community-Acquired Pneumonia Immunization Trial in Adults; CI, confidence interval; PCV13, 13-valent pneumococcal conjugate vaccine.

   

References:

Suaya J, Gessner BD, Chilson E, et al. 1442. Pneumonia hospitalizations averted with 13-valent pneumococcal conjugate vaccination of adults aged 18-64 years with diabetes in the united states. Open Forum Infect Dis. 2018;5(Suppl 1):S446. Published November 26, 2018. Accessed May 17, 2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252422/Huijts SM, van Werkhoven CH, Bolkenbaas M, Grobbee DE, Bonten MJM. Post hoc analysis of a randomized controlled trial: diabetes mellitus modifies the efficacy of the 13-valent pneumococcal conjugate vaccine in elderly. Vaccine. 2017;35(34):4444-4449.​​​​​​​

   

Please click the Prescribing Information link to view the safety and adverse events information of Prevenar 13®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

   

PP-PRV-IND-0268 July 2022

PCV13 in Diabetes

Dosing

Help protect your adult patients against pneumococcal pneumonia with single-dose administration

Learn more


Efficacy

Efficacy proven by the CAPiTA study

Learn more


Recommendations for Use

The ACIP recommends routine use of PCV13 among adults

Learn more

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These pages are not intended for patients or for members of the general public. The web pages contain promotional content. For the use only of Registered Medical Practitioners or a Hospital or a Laboratory. Full prescribing information available on request. For more details on, Who is a Registered Medical Practitioner, please visit "https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/acts_rules/2016DrugsandCosmeticsAct1940Rules1945.pdf", Page No. 39, Rule 2 part (ee), last accessed on 26th April2021.
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