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Burden of Disease
Burden of Disease
Risk Factors
Secondary Infections
Mechanism of Action
Prevention of Pneumococcal Disease
Need for Pneumococcal Vaccination
Cost-effectiveness of PCV13
Legacy of Prevenar
Safety
Conclusion
Dosing
Prevenar 13® Clinical Experience
Efficacy of Prevenar 13®
Effectiveness of Prevenar 13®
Indian Clinical Trials
Recommendations for Use
PCV13 in Pulmonology
PCV13 in Nephrology
PCV13 in Oncology
PCV13 in Rheumatology
PCV13 in Diabetes
PCV13 in HIV Infection
PCV13 in Cardiology
Resources
Clinical and Immunogenicity Data of Pneumococcal Vaccines in Patients With Diabetes
A study from the United States revealed that use of PCV13 in adults with diabetes, aged <65 years, could substantially reduce the incidence of pneumonia-related hospitalisations in these patients. Out of the 15 million adults aged <65 years, and with diabetes, in the US, there were 250,000 annual hospitalisations for CAP. The study revealed that PCV13 vaccination in this adult population with diabetes could avert 206,955 to 373,854 hospital days and 24,638 to 44,506 hospitalisations over a 5-year period. Moreover, to avert 1 hospital day and incidence of 1 hospitalization, the number of PCV13 vaccinations required in this population were 41 to 74 and 344 to 622, respectively. The study revealed that the number needed to vaccinate with PCV13 for averting 1 case of CAP in this population with diabetes was similar to the number shown in existing guidelines for elder patients. Therefore, the study concluded that use of PCV13 in adults aged <65 years might significantly reduce the number of pneumonia-related hospitalisations.1
A post hoc analysis of the CAPiTA trial reported that the effectiveness of PCV13 was significantly higher in patients with diabetes mellitus who were aged ≥65 years (P = 0.002). The vaccine effectiveness of PCV13 in elderly individuals with or without diabetes mellitus were 89.5% (95% CI, 65.5-96.8) and 24.7% (95% CI, −10.4 to 48.7), respectively.2
CAP, community-acquired pneumonia; CAPiTA, Community-Acquired Pneumonia Immunization Trial in Adults; CI, confidence interval; PCV13, 13-valent pneumococcal conjugate vaccine.
References:
Please click the Prescribing Information link to view the safety and adverse events information of Prevenar 13®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.
PP-PRV-IND-0661 July 2023
Help protect your adult patients against pneumococcal pneumonia with single-dose administration
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Efficacy proven by the CAPiTA study
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The ACIP recommends routine use of PCV13 among adults
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