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Burden of Disease

Burden of Disease

Description of the DiseaseGlobal EpidemiologyIndian EpidemiologyPneumococcal Disease and InfluenzaChallenges

Risk Factors
 

Risk Factors

Secondary Infections
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Secondary Infections

Mechanism of Action
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Mechanism of Action

Prevention of Pneumococcal Disease
 

Polysaccharide VaccineConjugate VaccineDifference

Need for Pneumococcal Vaccination

In ElderlyIn India

Cost-effectiveness of PCV13
 

NeedIndian StudiesGlobal Studies

Legacy of Prevenar
 

ManufacturingCRM197Activation and ConjugationPneumococcal Disease and InfluenzaDistributionVideos

Safety
 

Safety

Conclusion
 

Conclusion
Dosing

Dosing
 

Adults ≥18 Years of AgeAdults ≥50 Years of AgeCOVID VaccinationFlu Vaccination
Efficacy

Prevenar 13® Clinical Experience
 

IntroductionClinical Trials

Efficacy of Prevenar 13®
 

IntroductionStudyObjectiveMethodologyCriteriaResultsConclusion

Effectiveness of Prevenar 13® 
 

IntroductionObjectiveMethodologyAnalysisResultsLimitationsLearningsConclusion

Indian Clinical Trials
 

IntroductionStudy DesignResultsLimitationsConclusion
Recommendations for Use

Recommendations for Use
 

ACIP 2019NCCN 2020RSSDI 2020IMA GuidelinesIAOH Guidelines for Working AdultsClinical Practice Guidelines 2019 (ICS/NCCP)The Geriatric Society of India, 2015Indian Society of Nephrology
FAQs

PCV13 in Pulmonology
 

RoleComplicationsClinical DataRecommendations

PCV13 in Nephrology
 

RoleClinical DataRecommendations

PCV13 in Oncology
 

RoleClinical DataRecommendations

PCV13 in Rheumatology
 

RoleComplicationsDataRecommendationsConsensus

PCV13 in Diabetes
 

RoleComplicationsDataRecommendations

PCV13 in HIV Infection
 

RoleBurdenPulmonary InfectionDataEfficacyRecommendations

PCV13 in Cardiology
 

RoleBurdenComplicationsDataRecommendations
Resources

Resources

Summary of Prescribing InformationDownloadable ResourcesEvents and WebinarsLatest Articles

Recommendations

What Are the National and Global Recommendations for Pneumococcal Vaccination in Chronic Renal Diseases?

   

The CDC’s ACIP (2019) recommends 1 dose of PCV13 in persons aged ≥50 years with CRF.1 In patients with CRF aged between 50 and 64 years, 1 dose of PPSV23 is recommended ≥8 weeks after PCV13 and ≥5 years after any PPSV23 at the age of <65 years. In patients with CRF aged ≥65 years, 1 dose of PCV13 is recommended, if not received PCV13 previously. For PPSV23 in this age group, 1 dose is recommended ≥8 weeks after PCV13 and ≥5 years after any PPSV23 at <65 years.1 Other global guidelines which recommend the use of pneumococcal vaccines in patients with CKD are the Spanish Society of Nephrology (2014), the National Kidney Foundation (2015) and the High Council of Public Health of France (2017).2-4 Various national guidelines, like the Indian Society of Nephrology (2016), IMA (2018) and IAOH (2020) recommend pneumococcal vaccination in chronic renal diseases.5-7 The immunisation strategies should be formulated early in the course of progressive renal disease to maximise the likelihood of vaccine-induced immunity since the secondary antibody responses are less affected by immune compromise than primary antibody responses.5-7

ACIP, Advisory Committee on Immunization Practices; CDC, Centers for Disease Control and Prevention; CRF, chronic renal failure; IMA, Indian Medical Association; IAOH, Indian Association of Occupational Health; PCV13, 13-valent pneumococcal conjugate vaccine; PPSV23, 23-valent pneumococcal plain polysaccharide vaccine.

References:

Matanock A, Lee G, Gierke R, Kobayashi M, Leidner A, Pilishvili T. Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine among adults aged ≥65 years: updated recommendations of the Advisory Committee on Immunization Practices. MMWR Morb Mortal Wkly Rep. 2019;68(46):1069-1075.Gorostidi M, Santamaría R, Alcázar R, et al. Spanish Society of Nephrology document on KDIGO guidelines for the assessment and treatment of chronic kidney disease. Nefrologia. 2014;34(3):302-316.Vaccines and dialysis. What you need to know. National Kidney Foundation. Accessed May 17, 2022. https://www.kidney.org/sites/default/files/PatBro_Vaccines_and_%20Dialysis.pdfOpinion produced by the Specialized Commission on Communicable Diseases. High Council of Public Health, France. Accessed May 17, 2022.
https://www.hcsp.fr/Explore.cgi/Telecharger%3FNomFichier%3Dhcspa20170310_infectpneumocoquerecomadultes.pdf&prev=search
Indian Society of Nephrology Guidelines for Vaccination in Chronic Kidney Disease. 2016. Indian Society of Nephrology. Accessed May 17, 2022. http://isn-india.org/images/Indian-Society-of-Nephrology-Guidelines-for-vaccination-of-Chronic-Kidney-Disease.pdfTandon RN, Ravindra W, Monga VK. Life Course Immunization Guidebook. A Quick Reference Guide. Indian Medical Association; 2018. Accessed May 17, 2022. https://www.ima-india.org/ima/pdfdata/IMA_LifeCourse_Immunization_Guide_2018_DEC21.pdfKoul PA, Swaminathan S, Rajgopal T, et al. Adult immunization in occupational settings: a consensus on Indian experts. Indian J Occup Environ Med. 2020;24:3-15.

   

Please click the Prescribing Information link to view the safety and adverse events information of Prevenar 13®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

   

PP-PRV-IND-0268 July 2022

PCV13 in Nephrology

Dosing

Help protect your adult patients against pneumococcal pneumonia with single-dose administration

Learn more


Efficacy

Efficacy proven by the CAPiTA study

Learn more


Recommendations for Use

The ACIP recommends routine use of PCV13 among adults

Learn more

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