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Burden of Disease

Burden of Disease

Description of the DiseaseGlobal EpidemiologyIndian EpidemiologyPneumococcal Disease and InfluenzaChallenges

Risk Factors
 

Risk Factors

Secondary Infections
​​​​​​​

Secondary Infections

Mechanism of Action
​​​​​​​

Mechanism of Action

Prevention of Pneumococcal Disease
 

Polysaccharide VaccineConjugate VaccineDifference

Need for Pneumococcal Vaccination

In ElderlyIn India

Cost-effectiveness of PCV13
 

NeedIndian StudiesGlobal Studies

Legacy of Prevenar
 

ManufacturingCRM197Activation and ConjugationPneumococcal Disease and InfluenzaDistributionVideos

Safety
 

Safety

Conclusion
 

Conclusion
Dosing

Dosing
 

Adults ≥18 Years of AgeAdults ≥50 Years of AgeCOVID VaccinationFlu Vaccination
Efficacy

Prevenar 13® Clinical Experience
 

IntroductionClinical Trials

Efficacy of Prevenar 13®
 

IntroductionStudyObjectiveMethodologyCriteriaResultsConclusion

Effectiveness of Prevenar 13® 
 

IntroductionObjectiveMethodologyAnalysisResultsLimitationsLearningsConclusion

Indian Clinical Trials
 

IntroductionStudy DesignResultsLimitationsConclusion
Recommendations for Use

Recommendations for Use
 

ACIP 2019NCCN 2020RSSDI 2020IMA GuidelinesIAOH Guidelines for Working AdultsClinical Practice Guidelines 2019 (ICS/NCCP)The Geriatric Society of India, 2015Indian Society of Nephrology
FAQs

PCV13 in Pulmonology
 

RoleComplicationsClinical DataRecommendations

PCV13 in Nephrology
 

RoleClinical DataRecommendations

PCV13 in Oncology
 

RoleClinical DataRecommendations

PCV13 in Rheumatology
 

RoleComplicationsDataRecommendationsConsensus

PCV13 in Diabetes
 

RoleComplicationsDataRecommendations

PCV13 in HIV Infection
 

RoleBurdenPulmonary InfectionDataEfficacyRecommendations

PCV13 in Cardiology
 

RoleBurdenComplicationsDataRecommendations
Resources

Resources

Summary of Prescribing InformationDownloadable ResourcesEvents and WebinarsLatest Articles

Clinical Data

Clinical and Immunogenicity Data of Pneumococcal Vaccines in Lung Diseases

   

Evidence indicates that pneumococcal vaccinations in patients with COPD can help prevent CAP and acute exacerbations. Administration of pneumococcal vaccines early in the course of COPD can help in the maintenance of stable health status. However, both vaccination awareness and coverage are poor among these groups of patients.1

   

One of the important causes of exacerbations in COPD is S. pneumoniae. A prospective observational study evaluated the impact of PCV13 on the development of exacerbations in patients with COPD. As compared with the non-vaccinated group, the rate of hospitalisation was lower in the vaccinated group (32% vs. 18%). In the non-vaccinated group, the adjusted OR for risk of hospitalisation was 2.77 (P = 0.044). Therefore, the study revealed that in absence of PCV13, the risk of hospitalisation in patients with COPD is almost tripled.2

   

In the 2017 Cochrane systematic review, 12 randomised controlled trials were reviewed to determine the efficacy of injectable pneumococcal vaccines in patients with COPD. The study involved 2171 patients with COPD, the average age of participants being 66 years. The study revealed that vaccination with PCV13 and PPSV23 significantly lowered the likelihood of COPD exacerbation (OR, 0.60, 95% CI, 0.39-0.93). Some evidence indicated the benefits of pneumococcal vaccination in patients with COPD.3

   

A review of pneumococcal vaccine efficacy studies reported that the pneumococcal vaccine efficacy in individuals with underlying risk factors, such as COPD or chronic respiratory diseases, varied between −338% and 43%. The overall efficacy observed was 29% (95% CI, −39%-63%) in adults with chronic respiratory diseases, aged ≥50 years.4

   

A study analysed the effectiveness of PCV13 and PPSV23, and long-term formation of adaptive immunity in adult patients with COPD. The clinical effects of vaccination were assessed 1 and 4 years after immunisation. After 4 years, the study group vaccinated with PCV13/PPSV23 demonstrated a 50% decline in the number of patients with COPD exacerbations (P<0.001). At 1 year after vaccination, the vaccinated patients with COPD had elevated levels of IgG antibodies against PCV13 and PPSV23, as compared with the baseline. The study interpreted that initial immunisation with PCV13, followed by a booster dose of PPSV23, should be included in the basic therapy for patients with COPD.5

   

   

CAP, community-acquired pneumonia; CI, confidence interval; COPD, chronic obstructive pulmonary disease; OR, odds ratio; PCV13, 13-valent pneumococcal conjugate vaccine; PPSV23, 23-valent pneumococcal plain polysaccharide vaccine.

   

References:

Froes F, Roche N, Blasi F. Pneumococcal vaccination and chronic respiratory diseases. Int J Chron Obstruct Pulmon Dis. 2017;12:3457-3468.
Figueira-Gonçalves JM, Bethencourt-Martín N, Pérez-Méndez LI, et al. Impact of 13-valent pneumococcal conjugate polysaccharide vaccination in exacerbations rate of COPD patients with moderate to severe obstruction. Rev Esp Quimioter. 2017;30(4):269-275.Walters JA, Tang JN, Poole P, Wood-Baker R. Pneumococcal vaccines for preventing pneumonia in chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2017;1:CD001390.Tin Htar M, Stuurman AL, Ferreira G, et al. Effectiveness of pneumococcal vaccines in preventing pneumonia in adults, a systematic review and meta-analyses of observational studies. PLoS One. 2017;12(5):e0177985.Protasov AD, Zhestkov AV, Kostinov MP, et al. Analysis of the effectiveness and long-term results of formation of adaptive immunity in the use of various medications and vaccination schemes against pneumococcal infection in patients with chronic obstructive pulmonary disease. Ter Arkh. 2017;89(12. Vyp. 2):165-174.

   

Please click the Prescribing Information link to view the safety and adverse events information of Prevenar 13®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

   

PP-PRV-IND-0268 July 2022

PCV13 in Pulmonology

Dosing

Help protect your adult patients against pneumococcal pneumonia with single-dose administration

Learn more


Efficacy

Efficacy proven by the CAPiTA study

Learn more


Recommendations for Use

The ACIP recommends routine use of PCV13 among adults

Learn more

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