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ATTR-CMATTR-CMATTR-CM HomeAbout ATTR-CMMechanism of DiseaseWild-Type ATTR-CMHereditary ATTR-CMSuspect ATTR-CMDetect ATTR-CMResourcesEventsMaterialsVideos
Transthyretin amyloid cardiomyopathy

ATTR-CM is an underdiagnosed, progressive and infiltrative disease that can often be overlooked as a cause of heart failure.1,2

 Early diagnosis and treatment of ATTR-CM are critical to extending life3

Prognosis worsens rapidly with continued amyloid deposition, resulting in advancing organ dysfunction, a significant reduction in quality of life and ultimately death.1,4

Heart failure with preserved ejection fraction, especially in patients older than 60 years, warrants evaluation by a cardiologist.5,6

Untreated patients have a median survival of ~2 to 3.5 years once diagnosed with ATTR-CM.4

 Frequently asked questions about ATTR-CM Why does ATTR-CM matter to my practice and my patients? What are the ATTR-CM signs I should be looking for? What are the latest diagnostic techniques?
  • Non-invasive nuclear scintigraphy. Read more
  • Review the ATTR-CM diagnostic flowchart. View now
  • Multi-societal expert consensus recommendations. Learn more 
  • Diagnosing and collaborating with nuclear scintigraphy. Watch now
Meet ABE, the Amyloid Body of Evidence

ABE is an interactive experience designed to help locate various TTR amyloid deposition sites and to identify cardiac and noncardiac clues throughout the body. 

Tap a glowing hotspot or orange button to begin. About ATTR-CM > LoadingABE, Amyloid Body of Evidence; ATTR-CM, transthyretin amyloid cardiomyopathy.
 
 ReferencesWitteles RM, Bokhari S, Damy T, et al. Screening for transthyretin amyloid cardiomyopathy in everyday practice. JACC Heart Fail. 2019;7(8):709-716. doi:10.1016/j.jchf.2019.04.010Maurer MS, Hanna M, Grogan M, et al. Genotype and phenotype of transthyretin cardiac amyloidosis: THAOS (Transthyretin Amyloid Outcome Survey). J Am Coll Cardiol. 2016;68(2):161-172. doi:10.1016/j.jacc.2016.03.596Elliott P, Drachman BM, Gottlieb SS, et al. Long-term survival with tafamidis in patients with transthyretin amyloid cardiomyopathy. Circ Heart Fail. 2022;15:e008193. doi:10.1161/CIRCHEARTFAILURE.120.008193 Maurer MS, Elliott P, Comenzo R, Semigran M, Rapezzi C. Addressing common questions encountered in the diagnosis and management of cardiac amyloidosis. Circulation. 2017;135(14):1357-1377. doi:10.1161/CIRCULATIONAHA.116.024438 Garcia-Pavia P, Rapezzi C, Adler Y, et al. Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2021;42(16):1554-1568. doi:10.1093/eurheartj/ehab072Dorbala S, Ando Y, Bokhari S, et al. ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: part 1 of 2 – evidence base and standardized methods of imaging. J Nucl Cardiol. 2019;26(6):2065-2123. doi:10.1007/s12350-019-01760-6. Addendum: J Nucl Cardiol. Published online July 1, 2021. doi:10.1007/s12350-020-02455-zATTR-CM Discover more about ATTR-CM Which imaging modalities help raise the suspicion of ATTR-CM?

Gain a deeper understanding of echo and CMR.

 See the tools Loading Detect ATTR-CM noninvasively with nuclear scintigraphy6

Review the evidence and consensus recommendations for diagnosis.

 Learn more Loading
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