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AboutIntroducing Enbrel®Heritage of Enbrel®IndicationsTherapeutic IndicationsRheumatoid ArthritisJuvenile Idiopathic ArthritisPsoriatic ArthritisAxial SpondyloarthritisPsoriasis & Paediatric PsoriasisMechanism of actionMode of ActionHalf-lifeDosingDosingRheumatoid Arthritis, Psoriatic Arthritis & Axial SpondyloarthritisJuvenile Idiopathic ArthritisPsoriasisPaediatric PsoriasisAdministration & StorageAdministrationMYCLIC®StorageEfficacy & SafetyEfficacyRapid EffectivenessSustained EffectivenessEffectiveness With Monotherapy or Combination TherapySafetyTolerability Across IndicationsSummary of Prescribing InformationImmunogenicityImmunogenicity & Clinical ResponseImmunogenicity & Enbrel®Experience & InsightsExperience & InsightManufacturingPatient StoriesRheumatoid ArthritisPatient With an Increased Risk of Serious InfectionsMTX-IR PatientPatient Who Is Considering Starting a FamilyElderly-onset RA PatientYoung Patient Worried About the Lifelong Impact of RAYoung Patient Worried About Treatments That Lose Effectiveness Over TimeJuvenile Idiopathic ArthritisJuvenile PatientPatient Moving From Childhood to AdolescenceAxial SpondyloarthritisAS Patients With Heel EnthesitisAS Patients With Functional LimitationsAdvanced AS PatientsPsoriatic Arthritis & PsoriasisPsO Patient With Severe SymptomsPsO Patients With Cyclical SymptomsPsA Patient With Metabolic SyndromePsA Patient With Multiple Skin & Joint SymptomsSupport & ServicesSupport & ServicesUsing Enbrel®Summary of Prescribing InformationPatient ResourcesEventsMaterialsVideos

Juvenile Idiopathic Arthritis

The recommended dose of Enbrel® for patients with JIA is based on weight1:

  • 0.4 mg/kg (up to a maximum of 25 mg per dose) given as a subcutaneous injection with an interval of 3 to 4 days between the doses or
     
  • 0.8 mg/kg (up to a maximum of 50 mg per dose) given QW

Discontinuation of treatment should be considered in JIA patients who show no response after 4 months. The 10 mg vial strength may be more appropriate for children below the weight of 25 kg1

Adapted from Enbrel® LPD. Version LPDENB062021.

   

Discontinuation of treatment should be considered in patients with JIA who show no response after 4 months.1 

  • TNF plays an important role in the pathogenesis of JIA. High levels occur in both the serum and synovial fluid of children with JIA2
     
  • The trial for which etanercept was approved by the FDA was based on near 80% response rate2
     
  • Long-term follow-up in RCTs, ranging from 2.3 to 13 years, have demonstrated significant sustained response3,4
     
  • In the present study, etanercept was given in the dose of 0.4 mg/kg BIW or 0.8 mg/kg QW (9% started with QW, 34% switched to QW)5
     
  • Etanercept in JIA was associated with improved physical health and psychosocial functioning after 3 to 15 months of treatment. Additional improvement occurred after 27 months5

    

BIW, twice a week; FDA, Food and Drug Administration; JIA, juvenile idiopathic arthritis; QW, once a week; RCT, randomised controlled trial; TNF, tumour necrosis factor; TNFR, tumour necrosis factor receptor.

    

References:

Enbrel solution for injection. Local product document. Version LPDENB062021.Berard RA, Laxer RM. Etanercept (Enbrel) in the treatment of juvenile idiopathic arthritis. Expert Opin Biol Ther. 2013;13(11):1623-1630.Bang MH, Kim KN. Long term safety and efficacy of etanercept in juvenile idiopathic arthritis in a single center. J Rheum Dis. 2019;26(3):200-205.Lovell DJ, Reiff A, Jones OY, et al. Long-term safety and efficacy of etanercept in children with polyarticular-course juvenile rheumatoid arthritis. Arthritis Rheum. 2006;54(6):1987-1994.Prince FH, Geerdink LM, Borsboom GJ, et al. Major improvements in health-related quality of life during the use of etanercept in patients with previously refractory juvenile idiopathic arthritis. Ann Rheum Dis. 2010;69(1):138-142.

    

Please click the Prescribing Information link to view the safety and adverse events information of Enbrel®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

    

PP-ENB-IND-0814 August 2022

    

Dosing
Badge Enbrel® mechanism of Action

Enbrel® is a soluble tumour necrosis factor receptor fusion protein

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