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AboutIntroducing Enbrel®Heritage of Enbrel®IndicationsTherapeutic IndicationsRheumatoid ArthritisJuvenile Idiopathic ArthritisPsoriatic ArthritisAxial SpondyloarthritisPsoriasis & Paediatric PsoriasisMechanism of actionMode of ActionHalf-lifeDosingDosingRheumatoid Arthritis, Psoriatic Arthritis & Axial SpondyloarthritisJuvenile Idiopathic ArthritisPsoriasisPaediatric PsoriasisAdministration & StorageAdministrationMYCLIC®StorageEfficacy & SafetyEfficacyRapid EffectivenessSustained EffectivenessEffectiveness With Monotherapy or Combination TherapySafetyTolerability Across IndicationsSummary of Prescribing InformationImmunogenicityImmunogenicity & Clinical ResponseImmunogenicity & Enbrel®Experience & InsightsExperience & InsightManufacturingPatient StoriesRheumatoid ArthritisPatient With an Increased Risk of Serious InfectionsMTX-IR PatientPatient Who Is Considering Starting a FamilyElderly-onset RA PatientYoung Patient Worried About the Lifelong Impact of RAYoung Patient Worried About Treatments That Lose Effectiveness Over TimeJuvenile Idiopathic ArthritisJuvenile PatientPatient Moving From Childhood to AdolescenceAxial SpondyloarthritisAS Patients With Heel EnthesitisAS Patients With Functional LimitationsAdvanced AS PatientsPsoriatic Arthritis & PsoriasisPsO Patient With Severe SymptomsPsO Patients With Cyclical SymptomsPsA Patient With Metabolic SyndromePsA Patient With Multiple Skin & Joint SymptomsSupport & ServicesSupport & ServicesUsing Enbrel®Summary of Prescribing InformationPatient ResourcesEventsMaterialsVideos

Paediatric Psoriasis

Dosing with Enbrel® can be individualised based on the needs of each patient.1
The recommended dose of Enbrel® for paediatric patients with plaque PsO is based on weight1:

  • 0.8 mg/kg (up to a maximum of 50 mg per dose) QW for up to 24 weeks

    

Treatment should be discontinued in paediatric patients with PsO who show no response after 12 weeks. If re-treatment with Enbrel® is indicated, the above guidance on dosage and treatment duration should be followed.1

    

Enbrel® Significantly Improves Clinical Outcomes in Pediatric Patients With Plaque PsO2,3

   

Enbrel® Improves the severity of plaque PsO in children and adolescents as early as Week 2.2

    

Adapted from Paller AS, et al. 2008.

    

Paller AS. 2008. Methods: In this 48-week study, 211 patients with PsO (4-17 years of age) were initially randomly assigned to a double-blind trial of 12 QW subcutaneous injections of placebo or 0.8 mg of etanercept per kilogram of body weight (to a maximum of 50 mg), followed by 24 weeks of QW open-label etanercept. At Week 36, 138 patients underwent a second randomisation to placebo or etanercept to investigate the effects of withdrawal and retreatment. The primary endpoint was 75% or greater improvement from baseline in the PASI 75 at Week 12. Secondary endpoints included PASI 50, PASI 90, PGA of clear or almost clear of disease and safety assessments.

    

Enbrel® Helps Paediatric Patients With Plaque PsO Achieve Sustained Clinical Response3

   

PASI 50, PASI 75* and PASI* 90 responses compared with baseline throughout first 96 weeks of extension study (observed cases)3

   

   

Adapted from Paller AS, et al. 2010.

    

Paller AS. 2010: Methods: Patients who completed or received substantial treatment benefit in a 48-week, randomised, double-blind, placebo-controlled study (N=211) evaluating the efficacy and safety of QW etanercept (0.8 mg/kg) were enrolled in this 264-week OLE study.2

The primary endpoint was the occurrence of AEs. Secondary endpoints included PASI 50%, 75% and 90% responses compared with baseline; static PGA; and clear and clear/almost clear static PGA status. Results from a 96-week interim analysis are presented.2

   

PASI 75* at Week 96 (61%) was similar to the report at Week 12 for patients initially randomised to Enbrel® in the Paller clinical trial (57%)3

    

*Improvements in PASI 75, 50 and 90 over baseline in PASI.3

   

   

AE, adverse event; OLE, open-label extension; PASI, Psoriasis Area and Severity Index; PGA, physician global assessment; PsO, psoriasis; QW, once a week; TNFR, tumour necrosis factor receptor.

   

References:

Enbrel solution for injection. Local product document. Version LPDENB062021.Paller AS, Siegfried EC, Langley RG, et al. Etanercept treatment for children and adolescents with plaque psoriasis. N Engl J Med. 2008;358(3):241-251.Paller AS, Siegfried EC, Eichenfield LF, et al. Long-term etanercept in pediatric patients with plaque psoriasis. J Am Acad Dermatol. 2010;63(5):762-768.

   

Please click the Prescribing Information link to view the safety and adverse events information of Enbrel®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

    

PP-ENB-IND-0814 August 2022

    

Dosing
Badge Enbrel® mechanism of Action

Enbrel® is a soluble tumour necrosis factor receptor fusion protein

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