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Efficacy & SafetyAdultAdult Growth Hormone DeficiencyChildrenSmall for Gestational AgeTurner SyndromePrader-Willi SyndromeChronic Renal Insufficiency
Pediatric Growth Hormone Deficiency
Idiopathic Short Stature
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Chronic Renal Insufficiency

Efficacy of Genotropin® in normalisation of height at puberty in children with chronic renal insufficiency

   

   

Adapted from Haffner D, et al. 2000.1

   

*Significant differences from the previous period (P<0.001).
Significant differences from the children who were not treated with GH (P<0.001).

Study methods1

   

A total of 38 children (32 boys and 6 girls) from a German multicentre study who had reached final adult height at the time of analysis. The control group consisted of 50 children (31 boys and 19 girls) with chronic renal failure, who were matched with GH-treated children. The values are the 
means ± SD.

   

Safety2

   

Adverse events in the long-term treatment of children with growth disturbance due to chronic renal insufficiency

Scroll left to view table

   

Adapted from Genotropin. Local product document. 2022. LPDSOM052020.

   

   

*Reported in growth hormone deficient children treated with somatropin, but the incidence appears to be similar to that in children without growth hormone deficiency.
In general, these adverse effects are mild to moderate, arise within the first months of treatment, and subside spontaneously or with dose-reduction. The incidence of these adverse effects is related to the administered dose, the age of the patients, and possibly inversely related to the age of the patients at the onset of growth hormone deficiency.
Transient injection site reactions in children have been reported.
§Clinical significance is unknown.

   

ADR, adverse drug reaction; BMI, body mass index; GH, growth hormone; GHD, growth hormone deficiency; PWS, Prader-Willi syndrome; SD, standard deviation; SDS, standard deviation score.

   

References:

Haffner D, Schaefer F, Nissel R, Wühl E, Tönshoff B, Mehls O. Effect of growth hormone treatment on the adult height of children with chronic renal failure. German Study Group for Growth Hormone Treatment in Chronic Renal Failure. N Engl J Med. 2000;343(13):923-930.Genotropin. Local product document. Pfizer; 2022. Version LPDSOM052020.

   

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