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Children with ISS are shorter than children of the same age and gender.1
Dose-dependent effect of GH on final height in children with short stature without GHD
GH treatment that commenced as late as nearly the start of puberty in children with short stature and with ISS resulted in a dose-dependent increase in FH of approximately 1 SDS more than the control group randomised to no treatment. GH therapy had favorable safety profile and had no impact on the time until the onset of puberty.2
FH, final height; GH, growth hormone; GHD, growth hormone deficiency; ISS, idiopathic short stature; SDS, standard deviation score.
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