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Burden of Disease

Burden of Disease

Description of the DiseaseGlobal EpidemiologyIndian EpidemiologyPneumococcal Disease and InfluenzaChallenges

Risk Factors
 

Risk Factors

Secondary Infections
​​​​​​​

Secondary Infections

Mechanism of Action
​​​​​​​

Mechanism of Action

Prevention of Pneumococcal Disease
 

Polysaccharide VaccineConjugate VaccineDifference

Need for Pneumococcal Vaccination

In ElderlyIn India

Cost-effectiveness of PCV13
 

NeedIndian StudiesGlobal Studies

Legacy of Prevenar
 

ManufacturingCRM197Activation and ConjugationPneumococcal Disease and InfluenzaDistributionVideos

Safety
 

Safety

Conclusion
 

Conclusion
Dosing

Dosing
 

Adults ≥18 Years of AgeAdults ≥50 Years of AgeCOVID VaccinationFlu Vaccination
Efficacy

Prevenar 13® Clinical Experience
 

IntroductionClinical Trials

Efficacy of Prevenar 13®
 

IntroductionStudyObjectiveMethodologyCriteriaResultsConclusion

Effectiveness of Prevenar 13® 
 

IntroductionObjectiveMethodologyAnalysisResultsLimitationsLearningsConclusion

Indian Clinical Trials
 

IntroductionStudy DesignResultsLimitationsConclusion
Recommendations for Use

Recommendations for Use
 

ACIP 2019NCCN 2020RSSDI 2020IMA GuidelinesIAOH Guidelines for Working AdultsClinical Practice Guidelines 2019 (ICS/NCCP)The Geriatric Society of India, 2015Indian Society of Nephrology
FAQs

PCV13 in Pulmonology
 

RoleComplicationsClinical DataRecommendations

PCV13 in Nephrology
 

RoleClinical DataRecommendations

PCV13 in Oncology
 

RoleClinical DataRecommendations

PCV13 in Rheumatology
 

RoleComplicationsDataRecommendationsConsensus

PCV13 in Diabetes
 

RoleComplicationsDataRecommendations

PCV13 in HIV Infection
 

RoleBurdenPulmonary InfectionDataEfficacyRecommendations

PCV13 in Cardiology
 

RoleBurdenComplicationsDataRecommendations
Resources

Resources

Summary of Prescribing InformationDownloadable ResourcesEvents and WebinarsLatest Articles
H3 (Mobile)

Difference

Pneumococcal Plain Polysaccharide Vaccine and Conjugate Vaccine

   

Case-control and observational studies provide the majority of information pertaining to the protection afforded by PPSV23. Lower efficacy was reported in a widely referenced case control study in the United States of 983 IPD cases in which PPSV23 demonstrated 61% efficacy (95% CI, 47-72) in immunocompetent adults.1 In immunocompromised persons, the vaccine-type efficacy was much lower at 21% (95% CI, −55 to 60) and not statistically significant.2

Polysaccharide vaccines generally induce only short-term immunity, and do not elicit memory-boosting responses, and are not effective in the elicitation of immune responses in children aged <2 years. These characteristics are associated with an immune response elicited primarily by B-cells in secreting IgM.3

In this type of a response, polysaccharide(s) interact directly with B-cells and activate them expressing surface IgM antibodies specific to pneumococcal serotype-specific polysaccharide(s). The response to pneumococcal polysaccharides is independent of the dedicated antigen
presenting cells or T lymphocyte help. The absence of their involvement prevents the induction of an IgM to IgG antibody switch and the formation of memory B-cells (see figure below).3​​

   

Differences Between Plain Polysaccharide and Protein-polysaccharide Conjugate Vaccines4-6,7-9

   



CI, confidence interval; IPD, invasive pneumococcal disease; IgG, immunoglobulin G; IgM, immunoglobulin M; PPSV23, 23-valent pneumococcal plain polysaccharide vaccine.


References:

Jackson LA, Neuzil KM. Pneumococcal polysaccharide vaccines. In: Plotkin SA, Orenstein WA, Offit PA, eds. Vaccines. Elsevier; 2008:570-604.Shapiro ED, Berg AT, Austrian R, et al. The protective efficacy of polyvalent pneumococcal polysaccharide vaccine. N Engl J Med. 1991;325:1453-1460.Pletz MW, Maus U, Krug N, Welte T, Lode H. Pneumococcal vaccines: mechanism of action, impact on epidemiology and adaption of the species. Int J Antimicrob Agents. 2008;32(3):199-206.Orenstein W, Offit P, Edwards KM, Plotkin S. Vaccine immunology. In: Siegrist CA, ed. Plotkin’s Vaccines. Elsevier Inc.; 2008:17-36. Accessed May 17, 2022. http://www.who.int/immunization/documents/Elsevier_Vaccine_immunology.pdfPollard AJ, Perrett KP, Beverley PC. Maintaining protection against invasive bacteria with protein-polysaccharide conjugate vaccines. Nat Rev Immunol. 2009;9(3):213-220.Clutterbuck EA, Lazarus R, Yu L-M, et al. Pneumococcal conjugate and plain polysaccharide vaccines have divergent effects on antigen-specific B cells. J Infect Dis. 2012;205(9):1408-1416.Matanock A, Lee G, Gierke R, Kobayashi M, Leidner A, Pilishvili T. Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine among adults aged ≥65 years: updated recommendations of the Advisory Committee on Immunization Practices. MMWR Morb Mortal Wkly Rep. 2019;68(46):1069-1075.Glesby MJ, Brinson CC, Greenberg RN, et al. Immunogenicity and safety of 13-valent pneumococcal conjugate vaccine in HIV+ adults with prior 23-valent pneumococcal polysaccharide vaccination. Paper presented at: 20th Conference on Retroviruses and Opportunistic Infections (CROI); March 3-6, 2013; Atlanta, GA.French N, Nakiyingi J, Carpenter LM, et al. 23-valent pneumococcal polysaccharide vaccine in HIV-1-infected Ugandan adults: double-blind, randomised and placebo controlled trial. Lancet. 2000;355(9221):2106-2111.

   

Please click the Prescribing Information link to view the safety and adverse events information of Prevenar 13®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

   

PP-PRV-IND-0268 July 2022

Prevention of Pneumococcal Disease


Dosing

Help protect your adult patients against pneumococcal pneumonia with single-dose administration

Learn more


Efficacy

Efficacy proven by the CAPiTA study

Learn more


Recommendations for Use

The ACIP recommends routine use of PCV13 among adults

Learn more

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