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Burden of Disease

Burden of Disease

Description of the DiseaseGlobal EpidemiologyIndian EpidemiologyPneumococcal Disease and InfluenzaChallenges

Risk Factors
 

Risk Factors

Secondary Infections
​​​​​​​

Secondary Infections

Mechanism of Action
​​​​​​​

Mechanism of Action

Prevention of Pneumococcal Disease
 

Polysaccharide VaccineConjugate VaccineDifference

Need for Pneumococcal Vaccination

In ElderlyIn India

Cost-effectiveness of PCV13
 

NeedIndian StudiesGlobal Studies

Legacy of Prevenar
 

ManufacturingCRM197Activation and ConjugationPneumococcal Disease and InfluenzaDistributionVideos

Safety
 

Safety

Conclusion
 

ConclusionDosing

Dosing
 

Adults ≥18 Years of AgeAdults ≥50 Years of AgeCOVID VaccinationFlu VaccinationEfficacy

Prevenar 13® Clinical Experience
 

IntroductionClinical Trials

Efficacy of Prevenar 13®
 

IntroductionStudyObjectiveMethodologyCriteriaResultsConclusion

Effectiveness of Prevenar 13® 
 

IntroductionObjectiveMethodologyAnalysisResultsLimitationsLearningsConclusion

Indian Clinical Trials
 

IntroductionStudy DesignResultsLimitationsConclusionRecommendations for Use

Recommendations for Use
 

ACIP 2019NCCN 2020RSSDI 2020IMA GuidelinesIAOH Guidelines for Working AdultsClinical Practice Guidelines 2019 (ICS/NCCP)The Geriatric Society of India, 2015Indian Society of NephrologyFAQs

PCV13 in Pulmonology
 

RoleComplicationsClinical DataRecommendations

PCV13 in Nephrology
 

RoleClinical DataRecommendations

PCV13 in Oncology
 

RoleClinical DataRecommendations

PCV13 in Rheumatology
 

RoleComplicationsDataRecommendationsConsensus

PCV13 in Diabetes
 

RoleComplicationsDataRecommendations

PCV13 in HIV Infection
 

RoleBurdenPulmonary InfectionDataEfficacyRecommendations

PCV13 in Cardiology
 

RoleBurdenComplicationsDataRecommendationsResources

Resources

Summary of Prescribing InformationDownloadable ResourcesExplore EventsExplore VideosExplore MaterialsLatest Articles

Results

Of the 84,496 patients who were enrolled in the study, 42,240 received PCV13 and 42,256 received placebo. The mean follow-up time was 3.97 years in each group. Baseline characteristics were balanced between the 2 groups. The key results have been shown in figure and table given below.

The Study Achieved Its Primary and Secondary Objectives.1

   

Adapted from Bonten MJM, et al. 2015.

Primary and Secondary Objectives1

   

Adapted from Bonten MJM, et al. 2015.

   

The study clearly demonstrated significant reductions in pneumococcal VT-CAP and VT-IPD in adults aged 65 years and older. There were 45.56% fewer first episodes of VT-CAP among PCV13-vaccinated subjects than in subjects who received placebo (P = 0.0006). Additionally, compared with the placebo group, the PCV13 group experienced 45.00% fewer first episodes of VT-NB/NI CAP (P = 0.0067) and 75.00% fewer first episodes of VT-IPD (P = 0.0005). The safety results are depicted below.

   

Safety Results

Most local reactions and systemic events were mild or moderate in severity. Safety profile of PCV13 in this study was consistent with that observed in previous studies of PCV13 in adults.

   

   

   

CAP, community-acquired pneumonia; CI, confidence interval; IPD, invasive pneumococcal disease; NB/NI, non-bacteraemic/non-invasive; PCV13, 13-valent pneumococcal conjugate vaccine; VE, vaccine efficiency; VT, vaccine type; VT-CAP, vaccine-type community-acquired pneumonia; VT-IPD, vaccine-type invasive pneumococcal disease.

Reference:

Bonten MJM, Huijts S, Bolkenbaas M, et al. Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults. N Engl J Med. 2015;372(12):1114-1125.

   

Please click the Prescribing Information link to view the safety and adverse events information of Prevenar 13®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

   

PP-PRV-IND-0661 July 2023
Efficacy of Prevenar 13®

Dosing

Help protect your adult patients against pneumococcal pneumonia with single-dose administration

Learn more

Dosing

Help protect your adult patients against pneumococcal pneumonia with single-dose administration

Learn more

Dosing

Help protect your adult patients against pneumococcal pneumonia with single-dose administration

Learn more


Recommendations for Use

The ACIP recommends routine use of PCV13 among adults

Learn more


FAQs

FAQs related to different fields

Learn more
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