Pneumococcal PCVs prevent pneumococcal disease in infants, but their efficacy against pneumococcal CAP in adults 65 years of age or older is unknown. PPSV23 has demonstrated effectiveness in the prevention of IPDs.1 However, the prevention of pneumococcal CAP remained an unmet medical need, particularly since a large proportion of CAP is non-bacteraemic (i.e. non-invasive) pneumonia, and the question of the effectiveness of PPSV23 against non-invasive disease remains controversial. The authors of a meta-analysis commissioned by the WHO concluded that prevention of pneumococcal pneumonia cannot be achieved with PPSV23.2 Similarly, a 2013 Cochrane meta-analysis concluded that pneumococcal polysaccharide vaccines do not appear to prevent pneumonia (of all causes) or mortality in adults.3
CAP, community-acquired pneumonia; IPD, invasive pneumococcal disease; PCV13, 13-valent pneumococcal conjugate vaccine; PCV, pneumococcal conjugate vaccine; PPSV23, 23-valent pneumococcal polysaccharide vaccine; WHO, World Health Organization.
References:
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PP-PRV-IND-0661 July 2023
Help protect your adult patients against pneumococcal pneumonia with single-dose administration
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Help protect your adult patients against pneumococcal pneumonia with single-dose administration
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The ACIP recommends routine use of PCV13 among adults
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