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Burden of Disease

Burden of Disease

Description of the DiseaseGlobal EpidemiologyIndian EpidemiologyPneumococcal Disease and InfluenzaChallenges

Risk Factors
 

Risk Factors

Secondary Infections
​​​​​​​

Secondary Infections

Mechanism of Action
​​​​​​​

Mechanism of Action

Prevention of Pneumococcal Disease
 

Polysaccharide VaccineConjugate VaccineDifference

Need for Pneumococcal Vaccination

In ElderlyIn India

Cost-effectiveness of PCV13
 

NeedIndian StudiesGlobal Studies

Legacy of Prevenar
 

ManufacturingCRM197Activation and ConjugationPneumococcal Disease and InfluenzaDistributionVideos

Safety
 

Safety

Conclusion
 

Conclusion
Dosing

Dosing
 

Adults ≥18 Years of AgeAdults ≥50 Years of AgeCOVID VaccinationFlu Vaccination
Efficacy

Prevenar 13® Clinical Experience
 

IntroductionClinical Trials

Efficacy of Prevenar 13®
 

IntroductionStudyObjectiveMethodologyCriteriaResultsConclusion

Effectiveness of Prevenar 13® 
 

IntroductionObjectiveMethodologyAnalysisResultsLimitationsLearningsConclusion

Indian Clinical Trials
 

IntroductionStudy DesignResultsLimitationsConclusion
Recommendations for Use

Recommendations for Use
 

ACIP 2019NCCN 2020RSSDI 2020IMA GuidelinesIAOH Guidelines for Working AdultsClinical Practice Guidelines 2019 (ICS/NCCP)The Geriatric Society of India, 2015Indian Society of Nephrology
FAQs

PCV13 in Pulmonology
 

RoleComplicationsClinical DataRecommendations

PCV13 in Nephrology
 

RoleClinical DataRecommendations

PCV13 in Oncology
 

RoleClinical DataRecommendations

PCV13 in Rheumatology
 

RoleComplicationsDataRecommendationsConsensus

PCV13 in Diabetes
 

RoleComplicationsDataRecommendations

PCV13 in HIV Infection
 

RoleBurdenPulmonary InfectionDataEfficacyRecommendations

PCV13 in Cardiology
 

RoleBurdenComplicationsDataRecommendations
Resources

Resources

Summary of Prescribing InformationDownloadable ResourcesExplore EventsExplore VideosExplore MaterialsLatest Articles

Complications

Accumulating evidence indicates a frequent association between CAP and acute cardiac complications, including atrial fibrillation, HF and myocardial infarction.1 Multiple clinical studies have reported a 2- to eightfold increase in CVD risk within first 30 days after respiratory infections.2 CV complications develop in up to 30% of patients hospitalised for CAP, even up to 10 years thereafter.3 Among patients with pneumonia, acute myocardial infarction or unstable angina is reported in 5% of cases, new-onset arrhythmias in 12% cases and chronic heart failure in 14% cases. Studies have identified several risk factors for CV events in patients with CAP, such as older age, pre-existing CV or chronic respiratory conditions, hospital-stay, older age, severity of CAP and smoking.4


A matched cohort study investigated whether hospitalisation due to pneumonia was associated with increased risk of CVD. The study reported that pneumonia-related hospitalisation is associated with increased short-term (up to 1 year) and long-term (10 years) CVD risk, thereby indicating that pneumonia is a risk factor for CVD.2 Another multicentre study prospectively followed 1182 hospitalised patients with CAP for up to 30 days for CV events. The study reported intrahospital CV events in 32.2% of patients with CAP, while 2.4% patients died because of CV causes. The study revealed that CV events occur in around one-third of patients hospitalised for CAP, and such events are associated with a fivefold increase in CAP-associated mortality within 30 days.1


A recent retrospective observational study reported that patients with CVD are at higher risk of both CAP and HAP, and have higher frequency of ICU admissions. Additionally, regardless of comorbidities, age, gender and antibiotic use, pneumonia risk was particularly associated with HF, especially in elderly male patients.
Another recent systematic review and meta-analysis of 39 studies involving 92,188 patients revealed that overall cardiac complications occurred in 13.9% of CAP cases. Heart failure was observed in 7.2% of pooled patients, while acute coronary syndromes, arrhythmias and stroke occurred in 4.5%, 7.2% and 0.71% of patients with CAP, respectively.6



CAP, community-acquired pneumonia; CV, cardiovascular; CVD, cardiovascular disease; HAP, hospital-acquired pneumonia; HF, heart failure; ICU, intensive coronary unit.


References:

Violi F, Cangemi R, Falcone M, et al. Cardiovascular complications and short-term mortality risk in community-acquired pneumonia. Clin Infect Dis. 2017;64(11):1486-1493.Corrales-Medina VF, Alvarez KN, Weissfeld LA, et al. Association between hospitalization for pneumonia and subsequent risk of cardiovascular disease. JAMA. 2015;313(3):264-274.Restrepo MI, Reyes LF. Pneumonia as a cardiovascular disease. Respirology. 2018;23(3):250-259.Di Pasquale M, Henchi S, Vanoni N, Blasi F. Cardiovascular complications in patients with community-acquired pneumonia. Community Acquir Infect. 2017;4:23-31.Yeh JJ, Lin CL, Kao CH. Relationship between pneumonia and cardiovascular diseases: a retrospective cohort study of the general population. Eur J Intern Med. 2019;59:39-45.Tralhão A, Póvoa P. Cardiovascular events after community-acquired pneumonia: a global perspective with systematic review and meta-analysis of observational studies. J Clin Med. 2020;9(2):414.

   

Please click the Prescribing Information link to view the safety and adverse events information of Prevenar 13®.
For the use only of Registered Medical Practitioners or a Hospital or a Laboratory.

   

PP-PRV-IND-0661 July 2023

PCV13 in Cardiology

Dosing

Help protect your adult patients against pneumococcal pneumonia with single-dose administration

Learn more


Efficacy

Efficacy proven by the CAPiTA study

Learn more


Recommendations for Use

The ACIP recommends routine use of PCV13 among adults

Learn more

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